FlyBase Allele Report: Dmel\Cbs[5]

General Information

Symbol

Dmel\Cbs⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0362606

Feature type

allele

Associated gene

Dmel\Cbs

Associated Insertion(s)

TI{TI}Cbs⁵

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Zatsepina et al., 2020)

Mutagen

CRISPR/Cas9

(Shilova et al., 2020, Zatsepina et al., 2020)

Progenitor genotype

Associated Insertion(s)

TI{TI}Cbs⁵

Cytology

Description

The Cbs gene has been replaced with a mCherry-expressing reporter.

(Zatsepina et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

X:21,046,862..21,049,348 [+]

Comment:

The Cbs gene has been replaced with a mCherry-expressing reporter.

(Evgen'ev, 2020.11.5)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of homocystinuria

CEA

(Zatsepina et al., 2022)

CEC with Cth¹

(Zatsepina et al., 2022)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Cbs⁵, Cth¹ has short lived phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹, Tst1¹ has partially lethal phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹, Tst1¹ has some die during P-stage phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹ has female semi-sterile phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹ has partially lethal phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹, Tst1¹ has short lived phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹, Tst1¹ has female semi-sterile phenotype

(Shilova et al., 2025)

Phenotype Manifest In

Other

Statement

Reference

Cbs⁵, Cth¹ has ovary phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹ has ovariole phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹, Tst1¹ has ovary phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹, Tst1¹ has Malpighian tubule phenotype

(Shilova et al., 2025)

Cbs⁵, Cth¹, Tst1¹ has ovariole phenotype

(Shilova et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CBS(5)

(Shaposhnikov et al., 2022)

Cbs⁵

cbs5

(Zatsepina et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

Open Close