FlyBase Allele Report: Dmel\Dcp-1[ΔN.GMR]

General Information

Symbol

Dmel\Dcp-1^ΔN.GMR

Species

D. melanogaster

Name

FlyBase ID

FBal0105227

Feature type

allele

Associated gene

Dmel\Dcp-1

Associated Insertion(s)

Carried in Construct

P{GMR-ΔN-Dcp-1}

Also Known As

GMR-ΔN-dcp-1

Key Links

Transgenic product class

inframe_deletion

(Song et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Song et al., 2000)

Mutagen

in vitro construct

(Song et al., 2000)

Progenitor genotype

Carried in construct

P{GMR-ΔN-Dcp-1}

Cytology

Description

A truncated Dcp-1, missing the N-terminal prodomain, is driven by GMR sequences.

(Song et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

Dcp-1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Mallik and Lakhotia, 2009)

lethal - all die before end of pupal stage

(Mallik and Lakhotia, 2009)

some die during pupal stage

(Mallik and Lakhotia, 2009)

visible

(Leulier et al., 2006, Xu et al., 2006, Song et al., 2000)

Phenotype Manifest In

eye

(Mallik and Lakhotia, 2009, Leulier et al., 2006, Xu et al., 2006, Song et al., 2000)

pigment cell

(Song et al., 2000)

Detailed Description

Statement

Reference

Dcp-1^DeltaN.GMR eyes show complete loss of ommatidial integrity. 52% of Dcp-1^DeltaN.GMR differentiated pupae die.

(Mallik and Lakhotia, 2009)

Dcp-1^ΔN.GMR flies have a "spotted" eye phenotype.

(Xu et al., 2006)

Dcp-1^ΔN.GMR flies show a small and rough eye phenotype with pigment cell death. When two copies of P{GMR-ΔN-Dcp-1} are present the phenotype becomes stronger. The combination of Dcp-1^ΔN.GMR and Dcp-1^fl.GMR show an additive effect on the eye phenotype.

(Song et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Dcp-1^ΔN.GMR has visible phenotype, non-enhanceable by Scer\GAL4^GMR.PF/Strica^RNAi.UAS.cLa

(Leulier et al., 2006)

Dcp-1^ΔN.GMR has visible phenotype, non-enhanceable by Scer\GAL4^GMR.PF/Dronc^RNAi.UAS.cLa

(Leulier et al., 2006)

Suppressed by

Statement

Reference

Dcp-1^ΔN.GMR has lethal | pupal stage phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Dcp-1^ΔN.GMR has abnormal eye color phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

NOT suppressed by

Statement

Reference

Dcp-1^ΔN.GMR has visible phenotype, non-suppressible by Scer\GAL4^GMR.PF/Strica^RNAi.UAS.cLa

(Leulier et al., 2006)

Dcp-1^ΔN.GMR has visible phenotype, non-suppressible by Scer\GAL4^GMR.PF/Dronc^RNAi.UAS.cLa

(Leulier et al., 2006)

Dcp-1^ΔN.GMR has visible phenotype, non-suppressible by Drice¹⁷/Drice¹⁷

(Xu et al., 2006)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Dcp-1^ΔN.GMR has eye phenotype, non-enhanceable by Scer\GAL4^GMR.PF/Strica^RNAi.UAS.cLa

(Leulier et al., 2006)

Dcp-1^ΔN.GMR has eye phenotype, non-enhanceable by Scer\GAL4^GMR.PF/Dronc^RNAi.UAS.cLa

(Leulier et al., 2006)

Dcp-1^ΔN.GMR has phenotype, non-enhanceable by Drice^ΔN.GMR

(Song et al., 2000)

Dcp-1^ΔN.GMR has phenotype, non-enhanceable by Drice^fl.GMR

(Song et al., 2000)

Suppressed by

Statement

Reference

Dcp-1^ΔN.GMR has eye phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Dcp-1^ΔN.GMR has eye phenotype, suppressible by BacA\p35^GMR.PH

(Song et al., 2000)

NOT suppressed by

Statement

Reference

Dcp-1^ΔN.GMR has eye phenotype, non-suppressible by Scer\GAL4^GMR.PF/Strica^RNAi.UAS.cLa

(Leulier et al., 2006)

Dcp-1^ΔN.GMR has eye phenotype, non-suppressible by Scer\GAL4^GMR.PF/Dronc^RNAi.UAS.cLa

(Leulier et al., 2006)

Dcp-1^ΔN.GMR has eye phenotype, non-suppressible by Drice¹⁷/Drice¹⁷

(Xu et al., 2006)

NOT Enhancer of

Statement

Reference

Dcp-1^ΔN.GMR is a non-enhancer of phenotype of Drice^ΔN.GMR

(Song et al., 2000)

Dcp-1^ΔN.GMR is a non-enhancer of phenotype of Drice^fl.GMR

(Song et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Scer\GAL4^GMR.PF-mediated expression of P{Sym-UAS-Hsrω} nearly completely restores ommatidial integrity and eye pigmentation of Dcp-1[DeltaN.GMR] eyes. Pupal lethality is also suppressed.

(Mallik and Lakhotia, 2009)

The "spotted" eye phenotype caused by Dcp-1^ΔN.GMR is not suppressed by homozygosity for Ice¹⁷.

(Xu et al., 2006)

The rough eye phenotype is suppressed by the addition of BacA\p35^GMR.PH. The addition of Dcp-1^ΔN.GMR to Ice^fl.GMR or Ice^ΔN.GMR flies has no effect on eye morphology.

(Song et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Dcp-1^ΔN.GMR is rescued by Dcp-1^RNAi.UAS.cLa/Scer\GAL4^GMR.PF

(Leulier et al., 2006)

Comments

The eye phenotype observed in Dcp-1^ΔN.GMR animals is rescued by expression of Dcp-1^{dsRNA.Scer\UAS.cLa} under the control of Scer\GAL4^GMR.PF.

(Leulier et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Dcp-1^ΔN.GMR

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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