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General Information
Symbol
Dmel\S6kUAS.cWa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Watson
FlyBase ID
FBal0120644
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-S6K, UAS-dS6k
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of S6k.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of S6kScer\UAS.cWa under the control of Scer\GAL4GMR.PF results in eyes that are slightly larger than wild type.

Expression of S6kScer\UAS.cWa under the control of Scer\GAL4ap-md544 results in wings which are bent down due to overgrowth of the dorsal part.

Expression of S6kScer\UAS.cWa, under the control of Scer\GAL4GMR.PF, promotes modest overgrowth of the eye.

Expression of S6kScer\UAS.cWa under the control of Scer\GAL4ey.PH has no effect on eye size.

When S6kScer\UAS.cWa is driven by Scer\GAL4Act5C.PP in wild-type flies a significant resistance to rapamycin is conferred.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Statement
Reference
Suppressor of
Phenotype Manifest In
Suppressed by
NOT suppressed by
Statement
Reference

S6kUAS.cWa, Scer\GAL4ap-md544 has wing phenotype, non-suppressible by rictorΔ24

S6kUAS.cWa, Scer\GAL4ap-md544 has wing phenotype, non-suppressible by rictorΔ42

Enhancer of
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Expression of RpL8dsRNA.Scer\UAS partially suppresses the increase in eye size seen when S6kScer\UAS.cWa is expressed under the control of Scer\GAL4GMR.PF.

The wing phenotype caused by expression of S6kScer\UAS.cWa under the control of Scer\GAL4ap-md544 is not altered in a rictorΔ24 or rictorΔ42 background.

Flies co-expressing both S6kScer\UAS.cWa and raptordsRNA.Sym.Scer\UAS under the control of Scer\GAL4ap-md544 have normal wings.

Co-expression of S6kScer\UAS.cWa strongly enhances the Scer\GAL4GMR.PF>foxoGS9928 ommatidial phenotype.

The small ommatidium size caused by coexpression of gigScer\UAS.cTa and Tsc1Scer\UAS.cPa under the control of Scer\GAL4GMR.PF is suppressed by coexpression of S6kScer\UAS.cWa.

Expression of both Tsc1Scer\UAS.cTa and gigScer\UAS.cTa in the eye under the control of Scer\GAL4ey.PH results in a much smaller eye than normal. Coexpression of S6kScer\UAS.cWa suppresses the phenotype.

The addition of S6kScer\UAS.cWa (driven by Scer\GAL4Act5C.PP) to TorEP2353/TorEP2353 or TorEP2353/Tork17004 animals, rescues the Tor phenotype to viability.

Xenogenetic Interactions
Statement
Reference

Expression of Hsap\RPL8DN.Scer\UAS partially suppresses the increase in eye size seen when S6kScer\UAS.cWa is expressed under the control of Scer\GAL4GMR.PF.

Complementation and Rescue Data
Comments

Expression of S6kScer\UAS.cWa under the control of Scer\GAL4Act5C.PP rescues the lethality associated with S6kl-1.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
S6kScer\UAS.cWa
S6kUAS.cWa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Watson
Secondary FlyBase IDs
    References (8)