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Citation
Potter, C.J., Huang, H., Xu, T. (2001). Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.  Cell 105(3): 357--368.
FlyBase ID
FBrf0135685
Publication Type
Research paper
Abstract

Tuberous sclerosis complex is a dominant disorder that leads to the development of benign tumors in multiple organs. We have isolated a mutation in the Drosophila homolog of TSC1 (Tsc1). Cells mutant for Tsc1 are dramatically increased in size yet differentiate normally. Organ size is also increased in tissues that contain a majority of mutant cells. Clones of Tsc1 mutant cells in the imaginal discs undergo additional divisions but retain normal ploidy. We also show that the Tsc1 protein binds to Drosophila Tsc2 in vitro. Overexpression of Tsc1 or Tsc2 alone in the wing and eye has no effect, but co-overexpression leads to a decrease in cell size, cell number, and organ size. Genetic epistasis data are consistent with a model that Tsc1 and Tsc2 function together in the insulin signaling pathway.

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Related Publication(s)
Note

Insulin signaling: lessons from the Drosophila tuberous sclerosis complex, a tumor suppressor.
Montagne et al., 2001, Sci. STKE 2001(105): PE36 [FBrf0139801]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Aberrations (1)
    Alleles (16)
    Gene Groups (1)
    Genes (11)
    Human Disease Models (3)
    Physical Interactions (1)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (9)