FB2025_05 , released December 11, 2025
Allele: Dmel\mTorA948V
Open Close
General Information
Symbol
Dmel\mTorA948V
Species
D. melanogaster
Name
FlyBase ID
FBal0191669
Feature type
allele
Associated gene
Dmel\mTor
Associated Insertion(s)
Carried in Construct
Also Known As
TorA948V
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Zhang et al., 2006)
Mutagen
ethyl methanesulfonate
(Zhang et al., 2006)
Progenitor genotype
Cytology
Description

Mutation is within the HEAT-repeat domain of the Tor protein.

(Zhang et al., 2006)

Amino acid replacement: A948V.

(Zhang et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:13,008,240..13,008,240 [+]
Nucleotide change:

C13008240T

Amino acid change:

A948V | mTor-PA; A949V | mTor-PB

Reported amino acid change:

A948V

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Zhang et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      5-15% of TorA948V mutants are able to survive to adulthood. These escapers are about half the size of wild type and are developmentally delayed by 2 days at 25oC. Escaper flies are 10:1 female:male and both genders are sterile. Ovaries dissected from TorA948V females display arrested development and increased cell death at a previtellogenic stage. Testes are abnormal and have a grossly enlarged apical tip.

      (Zhang et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Tor[+]/mTorA948V is a suppressor | partially of partially lethal - majority die phenotype of Nprl21

      (Wei et al., 2016)

      Tor[+]/mTorA948V is a suppressor | partially of partially lethal - majority die phenotype of Df(3L)ED4515/Nprl31

      (Wei et al., 2016)

      Tor[+]/mTorA948V is a suppressor | partially of lethal | larval stage phenotype of gig193/gig109

      (Zhang et al., 2006)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The partial lethality of either Nprl21 or Nprl31 single mutants can be significantly suppressed by combination with a single copy of TorA948V.

      (Wei et al., 2016)

      Around 45% of TorA948V/+; gig109/gig193 flies survive to adulthood, while no gig109/gig193 survive to the pupal stage.

      (Zhang et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a mutation that is lethal in trans to the TorΔP deletion.

      (Zhang et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      TorA948V
      (Azuma et al., 2021, Zhou et al., 2021, Amoyel et al., 2016, Wei et al., 2016)
      TorAV
      (Wei et al., 2016)
      mTorA948V
      Name Synonyms
      Secondary FlyBase IDs
        References (5)