FlyBase Allele Report: Dmel\mTor[R248stop]

General Information

Symbol

Dmel\mTor^R248stop

Species

D. melanogaster

Name

FlyBase ID

FBal0190478

Feature type

allele

Associated gene

Dmel\mTor

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Zhang et al., 2006)

Mutagen

ethyl methanesulfonate

(Zhang et al., 2006)

Progenitor genotype

Cytology

Description

Mutation is within the HEAT-repeat domain of the Tor protein.

(Zhang et al., 2006)

Amino acid replacement: R248term.

(Zhang et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:13,005,725..13,005,725 [+]

Nucleotide change:

C13005725T

Amino acid change:

R248term | mTor-PA; R248term | mTor-PB

Reported amino acid change:

R248term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Zhang et al., 2006)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with mTor^ΔP)

(Zhang et al., 2006)

lethal - all die before end of second instar larval stage | recessive

(Zhang et al., 2006)

some die during second instar larval stage | recessive

(Zhang et al., 2006)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

mTor^2L1

(Zhang et al., 2006)

mTor^E161K

(Zhang et al., 2006)

mTor^Q528stop

(Zhang et al., 2006)

mTor^R97C

(Zhang et al., 2006)

mTor^A948V

(Zhang et al., 2006)

mTor^G2256D

(Zhang et al., 2006)

mTor^V2148D

(Zhang et al., 2006)

mTor^W1251R

(Zhang et al., 2006)

Rescued by

mTor^R248stop is rescued by mTor^+t9.4

(Zhang et al., 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a mutation that is lethal in trans to the Tor^ΔP deletion.

(Zhang et al., 2006)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Tor^R248stop

mTor^R248stop

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close