FB2025_04 , released October 2, 2025
Allele: Dmel\brat1
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General Information
Symbol
Dmel\brat1
Species
D. melanogaster
Name
FlyBase ID
FBal0001226
Feature type
allele
Associated gene
Dmel\brat
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Wright et al., 1976)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q872term.

(Connacher et al., 2024)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,170,759..19,170,759 [+]
Nucleotide change:

C19170759T

Reported nucleotide change:

C?T

Amino acid change:

Q872term | brat-PA; Q872term | brat-PB; Q872term | brat-PC; Q872term | brat-PE; Q872term | brat-PF

Reported amino acid change:

Q872term

(Connacher et al., 2024)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Most embryos laid by brat1/bratfs3 mothers have 4 or 5 abdominal segments rather than the normal 8.

      (Sonoda and Wharton, 2001)

      brat1/brat7 adults have a deformed thorax.

      (Wright, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      brat[+]/brat1 is a non-enhancer of visible phenotype of CycEJP

      (Brumby et al., 2004)
      Suppressor of
      Statement
      Reference

      brat[+]/brat1 is a suppressor of visible | dominant phenotype of gcmPyx

      (Popkova et al., 2012)
      NOT Suppressor of
      Statement
      Reference

      brat[+]/brat1 is a non-suppressor of visible phenotype of CycEJP

      (Brumby et al., 2004)
      Other
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      brat1 is an enhancer of eye phenotype of EBV\BRLF1GMR.PA

      (Adamson and Lajeunesse, 2012)
      NOT Enhancer of
      Statement
      Reference

      brat[+]/brat1 is a non-enhancer of eye phenotype of CycEJP

      (Brumby et al., 2004)
      Suppressor of
      Statement
      Reference

      brat[+]/brat1 is a suppressor of chaeta | increased number phenotype of gcmPyx

      (Popkova et al., 2012)
      NOT Suppressor of
      Statement
      Reference

      brat[+]/brat1 is a non-suppressor of eye phenotype of CycEJP

      (Brumby et al., 2004)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of either RbfHMS03004 or E2f2JF02828, under the control of Scer\GAL4nub.PU (using UAS-Dicer2 to enhance RNAi efficiency) in the brat1 mutant background results in variable minor adult wing defects. No wing phenotype is observed upon expression of either mip130HMS00462 or mip120HMS00461 in the brat1 mutants.

      (Miles et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Wright.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (13)