FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\bratfs3
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General Information
Symbol
Dmel\bratfs3
Species
D. melanogaster
Name
FlyBase ID
FBal0001252
Feature type
allele
Associated gene
Dmel\brat
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Schupbach and Wieschaus, 1991)
Progenitor genotype
Cytology
Description

Amino acid replacement: H802L.

(Arama et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,170,550..19,170,550 [+]
Nucleotide change:

A19170550T

Amino acid change:

H802L | brat-PA; H802L | brat-PB; H802L | brat-PC; H802L | brat-PE; H802L | brat-PF

Reported amino acid change:

H802L

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Arama et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AF195873
AAF13929
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Most embryos laid by brat1/bratfs3 mothers have 4 or 5 abdominal segments rather than the normal 8. Embryos laid by bratk06028/bratfs3 mothers have 5 to 8 abdominal segments. Most embryos laid by bratfs3/Df(2L)TE37C-7 mothers have 3 or 4 abdominal segments rather than the normal 8. Most embryos laid by bratfs3/bratfs1 mothers have 3 or 4 abdominal segments rather than the normal 8.

    (Sonoda and Wharton, 2001)

    45-55% of hemizygotes eclose as adults at 25oC. Homozygous larval brain tissue transplanted into the abdomens of adult female hosts shows unrestrained and invasive growth.

    (Wright, 1996)

    Ovaries contain a large number of mature eggs and they are retained.

    (Schupbach and Wieschaus, 1991)
    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer

    Schupbach.

    External Crossreferences and Linkouts ( 3 )
    Crossreferences
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Synonyms and Secondary IDs (4)
    Reported As
    Symbol Synonym
    bratPM43
    (Schupbach and Wieschaus, 1991)
    bratfs3
    (Tadros et al., 2007)
    fs(2)PM43
    l(2)37Cffs3
    (Gateff and Mechler, 1989)
    Name Synonyms
    Secondary FlyBase IDs
      References (7)