FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\bratfs1
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General Information
Symbol
Dmel\bratfs1
Species
D. melanogaster
Name
FlyBase ID
FBal0001250
Feature type
allele
Associated gene
Dmel\brat
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,170,466..19,170,466 [+]
Nucleotide change:

G19170466A

Amino acid change:

G774D | brat-PA; G774D | brat-PB; G774D | brat-PC; G774D | brat-PE; G774D | brat-PF

Reported amino acid change:

G774D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Sonoda and Wharton, 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      bratfs1 homozygous somatic clones in the larval brain do not present significant changes in cell number or in the proportion of mitotic cells at 72h after clone induction, as compared to control clones.

      (Reichardt et al., 2018)

      Embryos derived from bratfs1/Df(2L)TE37C-7 females display severe abdominal segmentation defects.

      (Cho et al., 2006)

      Mutant embryos have defects in abdominal segmentation. Most embryos laid by bratfs1/Df(2L)TE37C-7 mothers have 2 or 3 abdominal segments rather than the normal 8. Most embryos laid by bratfs3/bratfs1 mothers have 3 or 4 abdominal segments rather than the normal 8.

      (Sonoda and Wharton, 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Df(2L)Exel8040/bratfs1 is rescued by bratUAS.Tag:MYC/Scer\GAL4VP16.nanos.UTR

      (Komori et al., 2014)

      Df(2L)Exel8040/bratfs1 is rescued by bratΔB-boxes.UAS.Tag:MYC/Scer\GAL4VP16.nanos.UTR

      (Komori et al., 2014)

      Df(2L)Exel8040/bratfs1 is rescued by Scer\GAL4VP16.nanos.UTR/bratΔC-coil.UAS.Tag:MYC

      (Komori et al., 2014)

      bratfs1 is rescued by bratnanos.PC

      (Cho et al., 2006)

      bratfs1 is rescued by bratΔ63-721.UAS/Scer\GAL4VP16.nanos.UTR

      (Sonoda and Wharton, 2001)

      bratfs1 is rescued by bratUAS.cSa/Scer\GAL4VP16.nanos.UTR

      (Sonoda and Wharton, 2001)
      Not rescued by

      Df(2L)Exel8040/bratfs1 is not rescued by Scer\GAL4VP16.nanos.UTR/bratΔNHL.UAS.Tag:MYC

      (Komori et al., 2014)

      bratfs1 is not rescued by bratR837D.nanos

      (Cho et al., 2006)

      bratfs1 is not rescued by bratK882E.nanos

      (Cho et al., 2006)

      bratfs1 is not rescued by Scer\GAL4VP16.nanos.UTR/bratΔ724-1037.UAS

      (Sonoda and Wharton, 2001)

      bratfs1 is not rescued by bratΔ63-721.fs1.UAS/Scer\GAL4VP16.nanos.UTR

      (Sonoda and Wharton, 2001)

      bratfs1 is not rescued by Scer\GAL4VP16.nanos.UTR/bratfs1.UAS

      (Sonoda and Wharton, 2001)
      Comments

      Expression of either bratScer\UAS.T:Hsap\MYC, bratΔB-boxes.Scer\UAS.T:Hsap\MYC or bratΔC-coil.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 rescues the defects in abdominal segmentation seen in bratfs1/Df(2L)Exel8040 embryos.

      Expression of bratΔNHL.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 fails to rescue the defects in abdominal segmentation seen in bratfs1/Df(2L)Exel8040 embryos.

      (Komori et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Wright.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      bratG774D
      (Reichardt et al., 2018)
      bratfs1
      (Larson et al., 2022, Loewen et al., 2018, Reichardt et al., 2018, Komori et al., 2014, Tadros et al., 2007, Cho et al., 2006)
      fs(2)E60
      l(2)37Cffs1
      Name Synonyms
      Secondary FlyBase IDs
        References (9)