FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\chicunspecified
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General Information
Symbol
Dmel\chicunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0098272
Feature type
allele
Associated gene
Dmel\chic
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        chicunspecified homozygotes often have egg chamber packaging defects and egg chambers often have irregular actin. Delayed migration of the border cells relative to the outer follicle cells is seen in some egg chambers.

        (Urwyler et al., 2012)

        chic lethal mutants are severely defective in meiotic cytokinesis in males but not in cytokinesis in larval brain cells.

        (Somma et al., 2002)

        Mutant testes have ring canals (RCs) of variable sizes. The RCs present in spermatogonia and primary spermatocytes are usually normal. These apparently normal RCs persist throughout meiosis and are also found in spermatids. However, 15% of spermatids also show larger, often severely misshaped RC-like structures. These spermatids usually have a large nebenkern and 4 normally-sized nuclei.

        (Giansanti et al., 1999)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        chicunspecified is an enhancer of eye phenotype of EBV\BRLF1GMR.PA

        (Adamson and Lajeunesse, 2012)
        Other
        Statement
        Reference

        chic[+]/chicunspecified, sosie4 has follicle cell phenotype

        (Urwyler et al., 2012)

        chic[+]/chicunspecified, sosie4 has egg chamber phenotype

        (Urwyler et al., 2012)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        chicunspecified/sosie4 double heterozygotes often have egg chamber packaging defects and egg chambers often have irregular actin. Delayed migration of the border cells relative to the outer follicle cells is seen in more than 60% of egg chambers.

        (Urwyler et al., 2012)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        chicunspecified is rescued by chicotu.PW

        (Wellington, 2005.3)
        Partially rescued by

        chicunspecified is partially rescued by chicY120H.otu

        (Wellington, 2005.3)

        chicunspecified is partially rescued by chicY126Q.otu

        (Wellington, 2005.3)
        Not rescued by

        chicunspecified is not rescued by chicY126R.otu

        (Wellington, 2005.3)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        chicunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (6)