FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\gekΔPH.UAS
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General Information
Symbol
Dmel\gekΔPH.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0265917
Feature type
allele
Associated gene
Dmel\gek
Associated Insertion(s)
Carried in Construct
P{UAS-gek.ΔPH}
Key Links
Transgenic product class
inframe_deletion
(Gontang et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Gontang et al., 2011)
Mutagen
in vitro construct
(Gontang et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-gek.ΔPH}
Cytology
Description

UAS sequences drive expression of a mutant form of gek lacking the pleckstrin homology domain.

(Gontang et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
gek
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of gekΔPH.Scer\UAS under the control of Scer\GAL4Glass38-1 results in normal R cell axon targeting in third instar larvae. No photoreceptor morphology defects are seen in the eye discs, but adult animals have rough eyes.

      Expression of gekΔPH.Scer\UAS under the control of Scer\GAL4Glass38-1 in gekomb1080/Df(2R)e03819-f02302 mutant third instar larvae results in early termination of many R cell growth cones, with large clumps appearing in the optic stalk and the distal lamina.

      (Gontang et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4elav-C155/gekΔPH.UAS partially rescues gekomb1080

      (Gontang et al., 2011)
      Comments

      Expression of gekΔPH.Scer\UAS in pupal stage R cells under the control of Scer\GAL4elav-C155 rescues the axon targeting phenotypes seen in gekomb1080 homozygous clones. 83% of axons extend correctly, 12% mistarget and 5% do not extend. Premature stopping of R1-R6 axons above the lamina plexus is not observed. However, approximately 18% of R cells exhibit morphological defects, with apical domains extending too far towards the center of the ommatidium or being located basally. 6% of all R cell bodies are below the plane of the ommatidium. All remaining R cells appear normal.

      (Gontang et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      gekΔPH.Scer\UAS
      gekΔPH.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)