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FB2026_01
,
released March 12, 2026
hrp48, p50, linha, RRM7, l(2)02647
Please see the JBrowse view of Dmel\Hrb27C for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.46
Gene model reviewed during 5.45
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
4.1, 2.1 (northern blot)
1.7 (longest cDNA)
422 (aa)
48 (kD observed)
385 (aa); 48 (kD observed); 41 (kD predicted)
Interacts with sqd; the interaction is RNA-dependent and may be specific for sqd isoform A/sqdA (PubMed:15056611). Interacts with otu; the interaction is RNA-independent (PubMed:15056611).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hrb27C using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: extended 3' UTR isoform
Zygotic-specific isoforms of Hrb27C with long 3' UTR extensions were observed.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Hrb27C in JBrowse2-23
2-22.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
A sequence comparison and numerical analysis of the RRM-containing (RNA recognition motif) proteins suggests that functionally related RRM-containing proteins have significant sequence similarities in their RRMs.
The distribution of the hnRNP protein Hrb27C on nascent transcripts from polytene chromosomes has been studied.
Protein has been isolated by its ability to bind single-stranded DNA.
An Hrb27C cDNA clone has been isolated and sequenced.
Biochemical experiments support a mechanism for somatic inhibition of P-element intron 3 (IVS3) splicing in which the binding of a U1snRNP and multiprotein complexes to two exon pseudo 5' splice sites (F1 and F2) prevents U1snRNP binding to the accurate 5' splice site. A 50kD protein, Hrb27C contacts the F2 5' splice site.
Source for merge of: Hrb27C Rbp7
Source for merge of: Hrb27C linha
Source for merge of: Hrb27C p50
