Gene: Dmel\Hrb27C
hrp48, p50, linha, RRM7, l(2)02647
Please see the JBrowse view of Dmel\Hrb27C for information on other features
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Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.46
Gene model reviewed during 5.45
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
4.1, 2.1 (northern blot)
1.7 (longest cDNA)
422 (aa)
48 (kD observed)
385 (aa); 48 (kD observed); 41 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hrb27C using the Feature Mapper tool.
Comment: maternally deposited
Comment: extended 3' UTR isoform
Zygotic-specific isoforms of Hrb27C with long 3' UTR extensions were observed.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Hrb27C in GBrowse 22-23
2-22.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
Source for merge of: Hrb27C Rbp7
Source for merge of: Hrb27C linha
Source for merge of: Hrb27C p50
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
A sequence comparison and numerical analysis of the RRM-containing (RNA recognition motif) proteins suggests that functionally related RRM-containing proteins have significant sequence similarities in their RRMs.
The distribution of the hnRNP protein Hrb27C on nascent transcripts from polytene chromosomes has been studied.
Protein has been isolated by its ability to bind single-stranded DNA.
An Hrb27C cDNA clone has been isolated and sequenced.
Biochemical experiments support a mechanism for somatic inhibition of P-element intron 3 (IVS3) splicing in which the binding of a U1snRNP and multiprotein complexes to two exon pseudo 5' splice sites (F1 and F2) prevents U1snRNP binding to the accurate 5' splice site. A 50kD protein, Hrb27C contacts the F2 5' splice site.
