FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Hrb27C377
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General Information
Symbol
Dmel\Hrb27C377
Species
D. melanogaster
Name
FlyBase ID
FBal0160319
Feature type
allele
Associated gene
Dmel\Hrb27C
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Goodrich et al., 2004)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The wings of Hrb27C377 heterozygotes appear wild-type in appearance.

      (Klusza and Deng, 2010)

      <2% of eggs laid by Hrb27C02647/Hrb27C377 females exhibit any degree of dorsalisation. Nurse cell chromosomes in Hrb27C377/Hrb27C02647 females do not disperse properly after stage 6 of oogenesis.

      (Goodrich et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Hrb27C377/Hrb27C02647 has nurse cell & nuclear chromosome phenotype, suppressible | partially by otu104

      (Goodrich et al., 2004)
      Enhancer of
      Statement
      Reference

      Hrb27C377/Hrb27C02647 is an enhancer of egg chorion phenotype of sqd1/sqdK12

      (Goodrich et al., 2004)

      Hrb27C377/Hrb27C02647 is an enhancer of dorsal appendage phenotype of sqd1/sqdK12

      (Goodrich et al., 2004)

      Hrb27C377/Hrb27C02647 is an enhancer of egg operculum phenotype of sqd1/sqdK12

      (Goodrich et al., 2004)

      Hrb27C377/Hrb27C02647 is an enhancer of egg phenotype of sqd1/sqdK12

      (Goodrich et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A Hrb27C377 heterozygous background strengthens the wing margin phenotype found in poly2 homozygous mutants (compared to a wild-type background).

      (Klusza and Deng, 2010)

      Dispersion of nurse cell chromosomes in Hrb27C377/Hrb27C02647 females is increased by 2 copies of otu104. Dorsalisation of the eggs laid by sqd1/sqdK12 transheterozygotes is enhanced by Hrb27C02647/Hrb27C377 so that 100% show some degree of dorsalisation.

      (Goodrich et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Mary Lilly

      (Goodrich et al., 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hrb27C377
      (Klusza and Deng, 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)