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General Information
Symbol
Dmel\sqdK12
Species
D. melanogaster
Name
FlyBase ID
FBal0035700
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Of the eggs laid by sqd1/sqdK12 transheterozygotes, around 50 % exhibit some degree of dorsalisation: the least affected have widely spaced dorsal appendage and an enlarged operculum; intermediately affected have a single broad appendage that spans at least the width of the normal appendages; severely affected (<5%) have a crown of appendage material that surrounds the anterior circumference of the egg. Nurse cell chromosome morphology is normal in sqdK12 homozygotes.

Weak dorsalization of egg shell. Dorsal appendages are enlarged in 46% of eggs and ventrally fused in 54% of eggs. 9% of eggs contain embryos, which are dorsalized anteriorly and in half the cases have reduced filzkorper indicating weak posteriorly ventralization.

Embryos laid by hemizygous mothers are partially dorsalised. Heterozygotes with sqd1 are wild type with only a few dorsalised embryos.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Other
Statement
Reference

Hrb27C10280/Hrb27Ck16203, sqd1/sqdK12 has nurse cell & nuclear chromosome phenotype

Hrb27C10280/Hrb27Ck10413, sqd1/sqdK12 has nurse cell & nuclear chromosome phenotype

Additional Comments
Genetic Interactions
Statement
Reference

Dorsalisation of the eggs laid by sqd1/sqdK12 transheterozygotes is enhanced by Hrb27C10280/Hrb27Ck16203, so that >98% show some degree of dorsalisation, and by Hrb27C10280/Hrb27Ck10413, so that 100% show some degree of dorsalisation. In sqd1/sqdK12; Hrb27C10280/Hrb27Ck10413 and sqd1/sqdK12; Hrb27C10280/Hrb27Ck16203 females, nurse cell chromosomes fail to disperse after stage 6, but instead arrest in the blob like conformation typical at stage 6 of oogenesis.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)