FlyBase Allele Report: Dmel\Hrb27C[10280]

General Information

Symbol

Dmel\Hrb27C¹⁰²⁸⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0044460

Feature type

allele

Associated gene

Dmel\Hrb27C

Associated Insertion(s)

P{PZ}Hrb27C¹⁰²⁸⁰

Carried in Construct

Also Known As

l(2)10280, hrp48¹

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Campbell et al., 1995)

Progenitor genotype

Associated Insertion(s)

P{PZ}Hrb27C¹⁰²⁸⁰

Cytology

Description

P{PZ} insertion 1.5kb from the Hrb27C coding sequence.

(Hammond et al., 1997)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Goodrich et al., 2004)

lethal | recessive

(Harvie et al., 1998)

lethal - all die before end of larval stage | recessive

(Hammond et al., 1997)

lethal - all die during embryonic stage | recessive

(Campbell et al., 1995)

some die during embryonic stage | recessive

(Campbell et al., 1995)

some die during larval stage | recessive

(Hammond et al., 1997)

Phenotype Manifest In

egg (with Hrb27C^k10413)

(Goodrich et al., 2004)

egg (with Hrb27C^k16203)

(Goodrich et al., 2004)

egg chorion (with Hrb27C^k10413)

(Goodrich et al., 2004)

egg chorion (with Hrb27C^k16203)

(Goodrich et al., 2004)

Detailed Description

Statement

Reference

<3% of eggs laid by Hrb27C¹⁰²⁸⁰/Hrb27C^k16203 or Hrb27C¹⁰²⁸⁰/Hrb27C^k10413 females exhibit any degree of dorsalisation.

(Goodrich et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Hrb27C¹⁰²⁸⁰/Hrb27C^k16203 is an enhancer of egg chorion phenotype of sqd¹/sqd^K12

(Goodrich et al., 2004)

Hrb27C¹⁰²⁸⁰/Hrb27C^k16203 is an enhancer of dorsal appendage phenotype of sqd¹/sqd^K12

(Goodrich et al., 2004)

Hrb27C¹⁰²⁸⁰/Hrb27C^k16203 is an enhancer of egg operculum phenotype of sqd¹/sqd^K12

(Goodrich et al., 2004)

Hrb27C¹⁰²⁸⁰/Hrb27C^k16203 is an enhancer of egg phenotype of sqd¹/sqd^K12

(Goodrich et al., 2004)

Hrb27C¹⁰²⁸⁰/Hrb27C^k10413 is an enhancer of egg chorion phenotype of sqd¹/sqd^K12

(Goodrich et al., 2004)

Hrb27C¹⁰²⁸⁰/Hrb27C^k10413 is an enhancer of dorsal appendage phenotype of sqd¹/sqd^K12

(Goodrich et al., 2004)

Hrb27C¹⁰²⁸⁰/Hrb27C^k10413 is an enhancer of egg operculum phenotype of sqd¹/sqd^K12

(Goodrich et al., 2004)

Hrb27C¹⁰²⁸⁰/Hrb27C^k10413 is an enhancer of egg phenotype of sqd¹/sqd^K12

(Goodrich et al., 2004)

Hrb27C[+]/Hrb27C¹⁰²⁸⁰ is an enhancer of haltere sensillum phenotype of Ubx¹⁹⁵

(Burnette et al., 1999)

Hrb27C[+]/Hrb27C¹⁰²⁸⁰ is an enhancer of haltere sensillum phenotype of Ubx^9.22

(Burnette et al., 1999)

Hrb27C¹⁰²⁸⁰ is an enhancer of phenotype of Ubx¹⁹⁵

(Burnette et al., 1999)

Other

Statement

Reference

Hrb27C¹⁰²⁸⁰/Hrb27C^k16203, sqd¹/sqd^K12 has nurse cell & nuclear chromosome phenotype

(Goodrich et al., 2004)

Hrb27C¹⁰²⁸⁰/Hrb27C^k10413, sqd¹/sqd^K12 has nurse cell & nuclear chromosome phenotype

(Goodrich et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Dorsalisation of the eggs laid by sqd¹/sqd^K12 transheterozygotes is enhanced by Hrb27C¹⁰²⁸⁰/Hrb27C^k16203 so that >98% show some degree of dorsalisation, and by Hrb27C¹⁰²⁸⁰/Hrb27C^k16203 so that 100% show some degree of dorsalisation. In sqd¹/sqd^K12; Hrb27C¹⁰²⁸⁰/Hrb27C^k10413 and sqd¹/sqd^K12; Hrb27C¹⁰²⁸⁰/Hrb27C^k16203 females, nurse cell chromosomes fail to disperse after stage 6, but instead arrest in the blob like conformation typical at stage 6 of oogenesis.

(Goodrich et al., 2004)

Enhances the haltere phenotype of Ubx¹⁹⁵/+ such that halteres are enlarged, and average bristle number 3.6 (+-1.6 (SD); N=50). Enhances the haltere phenotype of Ubx^9.22/+ such that halteres are enlarged, and average bristle number 2.6 (+-1.5 (SD); N=46).

(Burnette et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Hrb27C⁰²⁶⁴⁷

(BDGP Project Members, 1994-1999)

Hrb27C^rF680

(BDGP Project Members, 1994-1999)

Partially rescued by

Hrb27C¹⁰²⁸⁰ is partially rescued by Hrb27C^hs.PH

(Hammond et al., 1997)

Not rescued by

Hrb27C¹⁰²⁸⁰ is not rescued by Hrb27C^Act5C.PH

(Hammond et al., 1997)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: snRNP70K⁰²¹⁰⁷. Complements: Rca1⁰³³⁰⁰. Complements: smt3⁰⁴⁸⁴¹. Complements: smt3¹⁰⁶³⁶.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Hrb27C¹⁰²⁸⁰

hrp48¹⁰²⁸⁰

(Nelson et al., 2007)

hrp48¹

(Burnette et al., 1999, Burnette et al., 1999, Burnette et al., 1999, Hammond et al., 1997)

l(2)02647¹⁰²⁸⁰

l(2)10280

(Vorbruggen et al., 2000, Vorbruggen et al., 2000, Campbell et al., 1995)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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