FlyBase Allele Report: Dmel\Ubx[195]

General Information

Symbol

Dmel\Ubx¹⁹⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0017409

Feature type

allele

Associated gene

Dmel\Ubx

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Lindsley and Zimm, 1992)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Castelli-Gair and Garcia-Bellido, 1990)

Description

Point mutation.

(Strutt and White, 1994)

UAG stop codon in mII. Inactivates Ubx isoforms Ia/b and IIa/b, but not IVa.

(Subramaniam et al., 1994)

Mutation causing a stop codon in the third Ubx exon.

(Castelli-Gair et al., 1992)

Single nucleotide change that introduces a nonsense codon in the exon at -53kb.

(Castelli-Gair et al., 1990)

Amino acid replacement: ??term.

(Castelli-Gair and Garcia-Bellido, 1990, Castelli-Gair et al., 1990, Mathog, 1990, Weinzierl et al., 1987)

Nucleotide substitution: G?A.

(Weinzierl et al., 1987)

Point mutation in the -50kb microexon, which generates a nonsense codon in the open reading frame of transcripts that use this microexon. Proteins encoded by these transcripts should terminate 7 amino acids before the start of the homeobox.

(Weinzierl et al., 1987)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:16,710,567..16,710,567 [-]

Nucleotide change:

G16710567A

Reported nucleotide change:

TGG?TAG

Amino acid change:

W288term | Ubx-PA; W271term | Ubx-PC; W262term | Ubx-PD; W279term | Ubx-PE

Reported amino acid change:

W?term

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement. See Figure 2c of FBrf0046283. Nonsense codon only causes termination in transcripts which use this exon. These transcripts should terminate 7 amino acids before the start of the homeobox.

(Weinzierl et al., 1987)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | dominant

(Burnette et al., 1999)

Phenotype Manifest In

abdominal 1 ventral denticle belt

(Alonso and Akam, 2003)

abdominal 2 ventral denticle belt | ectopic

(Alonso and Akam, 2003)

chordotonal organ & axon

(Subramaniam et al., 1994)

external sensory organ

(Subramaniam et al., 1994)

haltere

(Burnette et al., 1999)

Keilin's organ & abdominal segment 1

(Subramaniam et al., 1994)

metathoracic ventral denticle belt

(Alonso and Akam, 2003)

multidendritic neuron

(Subramaniam et al., 1994)

peripheral nervous system & parasegment 5

(Subramaniam et al., 1994)

peripheral nervous system & parasegment 6

(Subramaniam et al., 1994)

ventral denticle belt

(Weinzierl et al., 1987)

Detailed Description

Statement

Reference

Denticle belts of the third thoracic segment and the first abdominal segment are transformed to resemble those of the second thoracic segment.

(Alonso and Akam, 2003)

Haltere enlarged, average bristle number 0.8 (+-1.2 (SD); N=252).

(Burnette et al., 1999)

Transformation of the PNS patterns of parasegment 5 and 6 into copies of that of parasegment 4.

(Subramaniam et al., 1994)

Heterozygotes for Ubx¹⁹⁵ and a bxd breakpoint mutation show complete T3p to T2p ("pbx") and A1a to T3a ("bxd") transformations.

(Castelli-Gair et al., 1992)

Like Ubx¹.

(Lindsley and Zimm, 1992)

Does not affect the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52.

(Castelli-Gair and Garcia-Bellido, 1990)

Transvection positive with Ubx^bx-34e.

(Mathog, 1990)

Homozygotes complete embryogenesis and occasionally survive as third instar larvae. They have the characteristic Ubx phenotype of transformed denticle belts and three pairs of anterior spiracles. Ubx¹⁹⁵/Ubx^abx-2 transheterozygotes show extensive transformations of second thoracic leg to first leg structures. Many Ubx¹⁹⁵/Ubx^bxd-100 or Ubx¹⁹⁵ /Ubx^abx-2 flies eclose. Ubx¹⁹⁵ in trans with abx or bxd alleles has virtually no effect on the development of the adult nervous system; the pattern of commissures is indistinguishable from wild-type in Ubx¹⁹⁵/Ubx^bxd-100 adults. In Ubx^61d/Ubx^bxd-100 larvae A1 is transformed to T3, and a pair of presumptive leg neuromeres is formed in this transformed segment.

(Weinzierl et al., 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Ubx¹⁹⁵ has phenotype, enhanceable by Hrb27C¹⁰²⁸⁰

(Burnette et al., 1999)

Ubx¹⁹⁵ has phenotype, enhanceable by fl(2)d²

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(1)HC244

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(1)Sxl-bt

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(1)KA14

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(1)C246

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(1)sd72b

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(1)N19

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(1)HF396

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(2L)dp-79b

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(2L)TE29Aa-11

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(2L)Mdh

(Burnette et al., 1999)

Ubx¹⁹⁵ has phenotype, enhanceable by vir³

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(2L)Prl

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(2L)TW203

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(2L)TW158

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(2L)TW84

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3L)pbl-X1

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3L)pbl-NR

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3L)Rdl-2

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3L)29A6

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3L)fz-D21

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3L)fz-M21

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3L)brm11

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3L)st-f13

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3L)ri-79c

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3R)ME15

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3R)9A99

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3R)Antp17

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3R)by10

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3R)by62

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3R)M-Kx1

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3R)M86D

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by crn³

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3R)Delta-BX12

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3R)crb87-4

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3R)crb87-5

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3R)X3F

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(3R)awd-KRB

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(4)G

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Hrb27C[+]/Hrb27C¹⁰²⁸⁰

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by crn⁴

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by kz²⁶

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(1)64c18

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(1)JC19

(Burnette et al., 1999)

Ubx¹⁹⁵ has haltere sensillum phenotype, enhanceable by Df(1)dm75e19

(Burnette et al., 1999)

NOT Enhanced by

Statement

Reference

Ubx¹⁹⁵ has phenotype, non-enhanceable by Df(3R)ry506-85C

(Burnette et al., 1999)

Suppressed by

Statement

Reference

Ubx¹⁹⁵ has haltere phenotype, suppressible by Df(3R)l26c

(Burnette et al., 1999)

NOT suppressed by

Statement

Reference

Ubx¹⁹⁵ has phenotype, non-suppressible by Df(3R)ry506-85C

(Burnette et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Hrb27C¹⁰²⁸⁰ enhances the haltere phenotype of Ubx¹⁹⁵/+ such that halteres are enlarged, and average bristle number 3.6 (+-1.6 (SD); N=50).

(Burnette et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Lewis, Jan. 1968.

(Lindsley and Zimm, 1992)

Comments

The phenotype of a number of combinations of Ubx mutations has been investigated to determine the role of the bxd regulatory region in the modulation of Ubx expression.

(Castelli-Gair et al., 1992)

Phenotype in the PNS is qualitatively and quantitatively identical to that for complete absence of Ubx function.

(Subramaniam et al., 1994)

External Crossreferences and Linkouts ( 2 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

X05725

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

CAA29194

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ubx^17756.195

(Lindsley and Zimm, 1992)

Ubx¹⁹⁵

Name Synonyms

Secondary FlyBase IDs

References (20)

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