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General Information
Symbol
Dmel\vir3
Species
D. melanogaster
Name
FlyBase ID
FBal0040112
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Female germ cells homozygous for vir3 can complete oogenesis. Females carrying these homozygous germ line clones produce eggs (although fecundity is reduced) but when mated to vir+ males no larvae hatch (except for a few escapers). These phenotypes are rescued if the homozygous germ line clones are induced in females carrying vir+t10. The developmental potential of vir3/+ embryos derived from females carrying homozygous vir3 germ line clones and vir+ males is variable; some arrest at the blastoderm stage, others die as differentiated embryos or, rarely, as larvae. Whole larval gonads of the genotype XY ; vir3/Df(2R)vir130 form sperm after they are transplanted into the abdomen of adult females. Fertile males with integrated vir3/Df(2R)vir130 pole cells can be produced when XY ; vir3/Df(2R)vir130 pole cells are transplanted into agametic XY embryos.

Male homozygotes and male transheterozygotes with other EMS induced vir mutations die during larval or pupal stage, very few male escapers are present. Transheterozygotes with virts transform XX animals into intersexes at 29oC. Homozygous clones that occur in the sexually dimorphic regions of females differentiate male structures. Clones in males produce normal male structures. Sxl+/Sxl+;vir3/virts and Sxlf1/Sxl+;vir3/vir+ are viable but doubly heterozygous Sxlf1/Sxl+;vir3/virts females are lethal.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference

virunspecified/vir3 has lethal | female | larval stage phenotype, non-suppressible by SxlM1

virunspecified/vir3 has lethal | female | larval stage phenotype, non-suppressible by SxlM4

vir3 has lethal | female | larval stage phenotype, non-suppressible by msl-1γ222

vir3 has lethal | female | larval stage phenotype, non-suppressible by msl-2γ136

vir3 has lethal | female | larval stage phenotype, non-suppressible by mle9

Phenotype Manifest In
Enhancer of
Statement
Reference

vir3 is an enhancer of phenotype of Ubx9.22

vir3 is an enhancer of phenotype of Ubx195

Additional Comments
Genetic Interactions
Statement
Reference

The phenotype seen in females carrying homozygous germ line clones is not rescued if the germ line cells also carry SxlM1 or SxlM4.

Female lethality cannot be rescued by msl-1γ222, msl-2γ136 or mle9 mutations. The presence of SxlM1, SxlM4 or SxlF1.hs failed to rescue female lethality in vir transheterozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Homozygous larvae and heteroallelic larvae with vir2f, reared at 25oC, have msl-1 and mle associated with numerous sites along the paired X chromosomes.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
vir3
Name Synonyms
Secondary FlyBase IDs
    References (6)