partially constitutive due to roo insert near male-specific exon roo insertion
Viable SxlM1 bbflex-2 double mutant males have not been recovered. snf1 partially suppresses SxlM1 male lethality; snf1 SxlM1 double mutant males are viable at 18oC but are not recovered at 25oC. The temperature sensitive lethality of snf1 SxlM1 males is still seen if they are also mutant for bbflex-2; triple mutant males are recovered at 18oC, but not at 25oC.
FlyBase curator comment: subsequent publication (FBrf0134557) calls into question the validity of the genetic interaction between bbflex-2 and SxlM alleles (SxlM1 and SxlM4) stated in FBrf0111803. The suppression of the male lethality by bbflex-2 is slightly temperature dependent with fewer males surviving at 29oC than at 25oC. The resulting males are viable and fertile with no evidence of transformation.
Ovaries of ovoD1rv23/ovoD1rv22 females contain germline chambers in less than 20% of cases. The phenotype is not affected if the females are also carrying SxlM1. ovoD1rv22/ovoD1rv22; mle1/mle1 ovaries most often contain germ cells of male morphology rather than female morphology. This phenotype is partially suppressed by SxlM1; ovaries more often contain germ cells of female morphology rather than male morphology. ovoD1rv23/ovoD1rv23; mle1/mle5 ovaries most often contain germ cells of male morphology rather than female morphology. This phenotype is partially suppressed by SxlM1; ovaries more often contain germ cells of female morphology rather than male morphology. The sterility of ovoM2/ovoM2 and ovoM2/ovoe8K females is partially rescued if they are also carrying SxlM1. The partial sterility of ovoM2/ovoe7E females is rescued if they are also carrying SxlM1.
SxlM1 cannot rescue the XX progeny of females carrying homozygous vir2f germ line clones mated to homozygous vir2f males whether it is paternally or maternally inherited. Does not rescue the lethality of embryos derived from females with homozygous vir3 or vir4 germ line clones mated to vir+ males.
Females of the genotype Df(1)HC244, SxlM1/Sxlf1 are fertile and have no male transformations. SxlM1 rescues the zygotic lethal and sex transforming effect of the deficiency: this suggests that snf is involved in the activation of Sxl+ in females. Partial rescue of the maternal effect is seen. Males carrying SxlM1 can survive if they are also mutant for snf. They have several abnormalities: sex combs are a mosaic of male and female bristles, reduced and rotated genitalia, sternite 6 is covered in bristles and sternite 7 is sometimes present.