FlyBase Allele Report: Dmel\vir[6]

General Information

Symbol

Dmel\vir⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0050754

Feature type

allele

Associated gene

Dmel\vir

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Hilfiker et al., 1995)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | female | maternal effect | recessive

(Schutt et al., 1998)

lethal - all die before end of larval stage | female

(Hilfiker et al., 1995)

partially lethal - majority die | male | recessive

(Schutt et al., 1998)

some die during larval stage | female

(Hilfiker et al., 1995)

Phenotype Manifest In

Detailed Description

Statement

Reference

X chromosomal recombination frequencies in female germ cells homozygous for vir⁶ are significantly reduced compared to wild-type and there is an increased frequency of non-disjunction.

(Bopp et al., 1999)

Female germ cells homozygous for vir⁶ can complete oogenesis. Females carrying these homozygous germ line clones give rise only to male offspring when mated to vir⁺ or vir^2f males, and only a few percent of these males survive to adulthood. These phenotypes are rescued if the homozygous germ line clones are induced in females carrying vir^+t10. The daughters of females with homozygous germ line clones are rescued if the daughters carry Sxl^M4; Sxl^M4/+ ; vir⁶/+ animals develop as normal females. Sxl^M4/+ ; vir⁶/vir^2f animals derived from females carrying homozygous vir⁶ germ line clones mated to vir^2f/+ males survive, but are sexually transformed.

(Schutt et al., 1998)

Male homozygotes and male transheterozygotes with other EMS induced vir mutations die during larval or pupal stage, very few male escapers are present. Transheterozygotes with vir^ts transform XX animals into intersexes at 29^oC. Homozygous clones that occur in the sexually dimorphic regions of females differentiate male structures. Clones in males produce normal male structures. Foreleg and genital vir^2f/vir⁶ discs transplanted into vir⁺ hosts differentiate poorly developed male structures. Transplanted discs of homozygotes differentiate well developed male structures. Sxl⁺/Sxl⁺;vir⁶/vir^ts and Sxl^f1/Sxl⁺;vir⁶/vir⁺ are viable but doubly heterozygous Sxl^f1/Sxl⁺;vir⁶/vir^ts females are lethal.

(Hilfiker et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

vir^unspecified/vir⁶ has lethal | female | larval stage phenotype, non-suppressible by Sxl^F1.hs

(Hilfiker et al., 1995)

vir^unspecified/vir⁶ has lethal | female | larval stage phenotype, non-suppressible by Sxl^M1

(Hilfiker et al., 1995)

vir^unspecified/vir⁶ has lethal | female | larval stage phenotype, non-suppressible by Sxl^M4

(Hilfiker et al., 1995)

vir⁶ has lethal | female | larval stage phenotype, non-suppressible by msl-1^γ222

(Hilfiker et al., 1995)

vir⁶ has lethal | female | larval stage phenotype, non-suppressible by msl-2^γ136

(Hilfiker et al., 1995)

vir⁶ has lethal | female | larval stage phenotype, non-suppressible by mle⁹

(Hilfiker et al., 1995)

Other

Statement

Reference

Sxl^f1, vir⁶ has partially lethal phenotype

(Bopp et al., 1999)

Sxl^M4, vir⁶ has viable | female phenotype

(Schutt et al., 1998)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The frequency of recombination is further lowered if the vir⁶ germ cells also carry Sxl^f1, and the frequency of non-disjunction is further increased. The viability of Sxl^f1/+ ; vir⁶/vir⁶ females is severely reduced and escapers rarely produce eggs.

(Bopp et al., 1999)

Female lethality cannot be rescued by msl-1^γ222, msl-2^γ136 or mle⁹ mutations. The presence of Sxl^M1, Sxl^M4 or Sxl^F1.hs failed to rescue female lethality in vir transheterozygotes.

(Hilfiker et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

vir⁶ is rescued by vir^+t10

(Schutt et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

vir⁶

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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