FB2026_03 , released September 17, 2026
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St Johnston, D. (2006.10.4). Hrb27C[7E7-18] and Hrb27C[10B2-9] amino acid substitutions. 
FlyBase ID
FBrf0198712
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Personal communication to FlyBase
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(From FlyBase curator)
I am a curator for FlyBase, and am curating the genomic coordinates of
several mutants described in Huynh, et al., 2004 (Developmental Cell
 6:625-635 ).  In particular, the mutants linha7E7-18 (Hrb27C7E7-18) 
and linha10B2-9 (Hrb27C10B2-9) are described as G to A transitions 
that change the tryptophans (W) at positions 312 and 342 to asparagines
(N). However, any G to A transition in the Trp codon (TGG) must result 
in a stop codon (TAG or TGA); mutation to Asn requires that all three 
positions of the Trp codon be changed (TGG to AAT/C).
Would it be possible for you to clarify this issue?
(reply from D St Johnston)
We have now re-sequenced both (hrp48 alleles) and it 
turns out that you are correct, i.e. both alleles are premature 
termination codons (TGG -> TGA), not substitutions with Asn.
DOI
Related Publication(s)
Research paper

The Drosophila hnRNPA/B Homolog, Hrp48, Is Specifically Required for a Distinct Step in osk mRNA Localization.
Huynh et al., 2004, Dev. Cell 6(5): 625--635 [FBrf0174543]

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