FlyBase Gene Report: Dmel\Rbp6

General Information

Symbol

Dmel\Rbp6

Species

D. melanogaster

Name

RNA-binding protein 6

Annotation Symbol

CG32169

Feature Type

protein_coding_gene

FlyBase ID

FBgn0260943

Gene Model Status

Current

Stock Availability

25 publicly available

Gene Summary

RNA-binding protein 6 (Rbp6) encodes a paralog of the RNA-binding protein encoded by msi. In contrast to msi, Rbp6 mutants are viable and fertile, with only a slight delay in eclosion. The product of Rbp6 may have roles in response to fungal infection and aggressive behavior. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

RRM6

Key Links

Genomic Location

Cytogenetic map

73E5-74A1

Sequence location

3L:17,058,774..17,238,212 [-]

Recombination map

3-45

RefSeq locus

NT_037436 REGION:17058774..17238212

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables mRNA binding

inferred from biological aspect of ancestor with PANTHER:PTN004472239

(GO Reference Genome Project, 2011-)

enables nucleic acid binding

inferred from electronic annotation with InterPro:IPR035979

(InterPro Project Members, 2004-)

enables poly(U) RNA binding

inferred from sequence or structural similarity with UniProtKB:Q920Q6

(Gene Ontology Curators, 2002-)

enables RNA binding

inferred from electronic annotation with InterPro:IPR000504, InterPro:IPR034126

(InterPro Project Members, 2004-)

enables single-stranded RNA binding

inferred from sequence or structural similarity with UniProtKB:Q920Q6

(Gene Ontology Curators, 2002-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in regulation of translation

inferred from biological aspect of ancestor with PANTHER:PTN004472239

(GO Reference Genome Project, 2011-)

involved_in stem cell development

inferred from sequence or structural similarity with UniProtKB:Q920Q6

(Gene Ontology Curators, 2002-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN002690062

(GO Reference Genome Project, 2011-)

located_in cytoplasm

inferred from sequence or structural similarity with UniProtKB:Q920Q6

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the Musashi family. (Q9VVE5)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).

(UniProt, Q9VVE5)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Rbp6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VVE5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.

Gene model reviewed during 5.41

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Rbp6-RA

FBtr0075285

NM_168718

2173

369

Rbp6-RB

FBtr0113427

NM_001104161

4368

499

Rbp6-RC

FBtr0113428

NM_001104162

2260

257

Rbp6-RD

FBtr0290066

NM_001144489

1441

162

Rbp6-RE

FBtr0310005

NM_001259883

8403

259

Rbp6-RF

FBtr0310006

NM_001259884

4918

225

Rbp6-RG

FBtr0333861

NM_001275050

9015

371

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Rbp6-PA

FBpp0075045

40.1

369

7.62

FBpp0112339

53.5

499

8.76

NP_001097631

ABW08559

Rbp6-PC

FBpp0112340

27.5

257

7.60

NP_001097632

ABW08560

Rbp6-PD

FBpp0288505

17.9

162

7.50

FBpp0301711

27.6

259

7.65

FBpp0301712

23.7

225

9.33

FBpp0305994

40.2

371

7.65

M9PCV2

NP_001261979

AGB94672

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rbp6 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.69

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 17

organism

Comment: extended 3' UTR isoform

(Hilgers et al., 2011)

embryonic stage 13 -- 16

dorsal pharyngeal muscle cell

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

embryonic central brain neuron

(Fisher et al., 2012)

embryonic/larval corpus allatum

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

lateral cord neuron

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

embryonic stage 15 -- 17

prothoracic gland

(Siddall et al., 2012)

third instar larval stage

prothoracic gland

(Siddall et al., 2012)

larval brain

(Siddall et al., 2012)

larval ventral nerve cord

(Siddall et al., 2012)

adult stage | male

testis

(Siddall et al., 2012)

adult stage | female

ovariole

(Siddall et al., 2012)

Additional Descriptive Data

A probe that detects transcripts Rbp6-RA and Rbp6-RB (which produce the long isoforms) is detected in the ring gland in embryos and larvae, in the larval brain and ventral ganglion, and in adult ovary and testis.

(Siddall et al., 2012)

Zygotic-specific isoforms of Rbp6 with long 3' UTR extensions were observed.

(Hilgers et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

eye disc posterior to the morphogenetic furrow

(Siddall et al., 2012)

ring gland

(Siddall et al., 2012)

larval brain

(Siddall et al., 2012)

adult stage | male

cyst cell of testis

(Siddall et al., 2012)

adult stage | female

oocyte

(Siddall et al., 2012)

nurse cell

(Siddall et al., 2012)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Rbp6 protein is detected in the eye disc posterior to the morphogenetic furrow, the ring gland, and non-proliferative cells of the brain in third instar larvae. It is observed in somatic cyst cells in the testis and in the oocyte and nurse cells in the adult ovary.

(Siddall et al., 2012)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rbp6 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Rbp6

View exonic expression by tissue for Dmel\Rbp6

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0260943

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39919/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0260943

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052169

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0260943

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32169

Flygut - An atlas of the Drosophila adult midgut

FBgn0260943

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 30 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Rbp6

Transgenic constructs containing regulatory region of Rbp6

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

Rbp6^GD15236

viable

viable, with Scer\GAL4^pnr-MD237

Rbp6^GD15236

viable, with Scer\GAL4^tin.CΔ4

Rbp6^GD15236

viable (with Rbp6¹)

Rbp6³

viable (with Rbp6³)

Rbp6¹

Sterility

Allele

fertile

fertile (with Rbp6¹)

Rbp6³

fertile (with Rbp6³)

Rbp6¹

Other Phenotypes

Allele

increased cell death, with Scer\GAL4^{VP16.nanos.UTR}

Rbp6^UAS.cSa

Phenotype manifest in

Allele

basement membrane (with Rbp6¹)

Rbp6³

basement membrane (with Rbp6³)

Rbp6¹

hub cell (with Rbp6¹)

Rbp6³

hub cell (with Rbp6³)

Rbp6¹

male germline cell, with Scer\GAL4^{VP16.nanos.UTR}

Rbp6^UAS.cSa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (71)

Hsap\MSI2

14 of 14

Yes

Hsap\MSI1

11 of 14

Yes

Hsap\DAZAP1

5 of 14

Hsap\HNRNPDL

2 of 14

Hsap\RBM24

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\RBMY1D

1 of 14

Hsap\RBMY1E

1 of 14

Yes

Hsap\RBMY1F

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

144

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (38)

Rnor\Msi2

13 of 14

Yes

Rnor\Msi1

11 of 14

Yes

5 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Rbm31y

1 of 14

Rnor\Rbm38

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (45)

Mmus\Msi2

14 of 14

Yes

Mmus\Msi1

11 of 14

Yes

Mmus\Dazap1

5 of 14

Mmus\Hnrnpdl

2 of 14

Mmus\Rbm24

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (37)

Xtro\msi2

11 of 13

Yes

Xtro\msi1

9 of 13

Yes

Xtro\tram2

9 of 13

Yes

4 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (45)

Drer\msi2a

14 of 14

Yes

Drer\msi2b

14 of 14

Yes

Drer\msi1b

10 of 14

Yes

Drer\LOC100537556

7 of 14

Yes

Drer\dazap1

5 of 14

Drer\msi1a

5 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch1073-335m2.2

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (30)

Cele\msi-1

12 of 14

Yes

Cele\hrpa-2

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (33)

Agam\AgaP_AGAP006656

11 of 12

Yes

5 of 12

4 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (104)

Atha\AT4G26650

9 of 13

Yes

Atha\AT5G55550

9 of 13

Yes

Atha\AT3G07810

8 of 13

Yes

Atha\AT2G33410

7 of 13

Atha\AT4G14300

7 of 13

Atha\AT5G47620

7 of 13

Yes

Atha\AT3G13224

4 of 13

Yes

Atha\AT1G17640

3 of 13

Yes

Atha\RBP1

3 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT2G35410

1 of 13

Atha\AT2G37220

1 of 13

Atha\AT2G37510

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT3G52660

1 of 13

Atha\AT4G13860

1 of 13

Yes

Atha\AT4G36960

1 of 13

Atha\AT5G06210

1 of 13

Yes

Atha\AT5G08695

1 of 13

Atha\AT5G11412

1 of 13

Atha\AT5G19030

1 of 13

Yes

Atha\AT5G19350

1 of 13

Atha\AT5G19960

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\GR-RBP5

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\HRP1

7 of 13

Yes

Scer\MRD1

1 of 13

Scer\NOP13

1 of 13

Yes

Scer\NPL3

1 of 13

Scer\NSR1

1 of 13

Yes

Scer\PAB1

1 of 13

Scer\PUB1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (7)

Spom\SPBC660.15

6 of 12

Yes

Spom\gar2

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Rbp6. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (38)

msi

9 of 13

Hrb27C

7 of 13

sqd

4 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Syp

2 of 13

B52

1 of 13

bol

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

fne

1 of 13

hfp

1 of 13

lark

1 of 13

LS2

1 of 13

Ppil4

1 of 13

Rbp9

1 of 13

Ref1

1 of 13

rin

1 of 13

SC35

1 of 13

Secp43

1 of 13

SF2

1 of 13

snRNP-U1-70K

1 of 13

Sxl

1 of 13

TBPH

1 of 13

tra2

1 of 13

trv

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Rbp6^d08411

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^{M337V.UAS.Tag:MYC}

(Markmiller et al., 2018)

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^{R521C.UAS.Tag:HA}

(Markmiller et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MSI2; musashi RNA binding protein 2

14 of 14

607897

MSI1; musashi RNA binding protein 1

11 of 14

603328

DAZAP1; DAZ associated protein 1

5 of 14

607430

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Rbp6 - orb2

anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry

(Khan et al., 2015, White-Grindley et al., 2014)

Rbp6 - smg

anti tag coimmunoprecipitation, western blot

(Khan et al., 2015)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65211

DroID - A comprehensive database of gene and protein interactions.

FBgn0260943

MIST (protein-protein) - An integrated Molecular Interaction Database

39919

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

mRNA surveillance pathway

Class of Gene

gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-45

Cytogenetic map

73E5-74A1

Sequence location

3L:17,058,774..17,238,212 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

73E5-74A1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-45

(FlyBase, 2016)

3-40.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (25)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

71764

w¹¹¹⁸; P{VT032110-GAL4.DBD}attP2

71765

w¹¹¹⁸; P{VT032162-GAL4.DBD}attP2

25330

w¹¹¹⁸; Mi{ET1}Rbp6^MB06777

61324

y¹ v¹; P{TRiP.HMJ23159}attP40

63920

w¹¹¹⁸; PBac{IT.GAL4}Rbp6^0950-G4

Korea

12691

P{VT032110-GAL4}attP2

15163

P{VT032162-GAL4}attP2

14510

P{VT032110-lexA}attP2

17123

P{VT032162-lexA::GADfl}attP40

NIG-Fly

32169R-2

P{NIG.32169R}2

HMJ23159

y¹ v¹; P{TRiP.HMJ23159}attP40/CyO

VDRC

v29799

w¹¹¹⁸; P{GD15236}v29799/CyO

More stocks available...

Genomic Clones (73)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (19)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP20655

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0260943

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0260943

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Siddall et al., 2012)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

A sequence comparison and numerical analysis of the RRM-containing (RNA recognition motif) proteins suggests that functionally related RRM-containing proteins have significant sequence similarities in their RRMs.

(Kim and Baker, 1993)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG32169 BcDNA:RE25373

(Rana, 2004.7.2)

Source for merge of: Rbp6 CG32169

(FlyBase, 1996-)

Source for merge of: CG14055 CG14056 CG6573

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG14055, CG14056 and CG6573 merged as CG32169 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

BcDNA:RE25373

CG14055

CG14056

(Stanyon et al., 2004)

CG32169

(Hosono et al., 2015, Ashwal-Fluss et al., 2014, White-Grindley et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Siddall et al., 2012, Perkins et al., 2009, Manak et al., 2006)

CG6573

RRM6

(Kim, 1993.3.10)

rbp6

(Hilgers et al., 2011)

rrm6

(Kim and Baker, 1993)

Name Synonyms

CG32169

RNA-binding protein 6

(Siddall et al., 2012, Dalton et al., 2010)

Secondary FlyBase IDs

FBgn0010260
FBgn0052169
FBgn0036699
FBgn0036700
FBgn0036701
FBgn0063045

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 61 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39919

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VVE5

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VVE5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VVE5

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0260943

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39919/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0260943

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0260943

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32169

MARRVEL_MODEL - MARRVEL (model organism gene)

39919

Linkouts

BioGRID - A database of protein and genetic interactions.

65211

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0260943

DroID - A comprehensive database of gene and protein interactions.

FBgn0260943

DRSC - Results frm RNAi screens

FBgn0260943

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052169

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0260943

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32169

Flygut - An atlas of the Drosophila adult midgut

FBgn0260943

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0260943

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

mRNA surveillance pathway

MIST (protein-protein) - An integrated Molecular Interaction Database

39919

References (79)

The following external sites may use different assemblies or annotations than FlyBase.

-0.69

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