FB2026_02 , released June 18, 2026
Allele: Dmel\Rbp61
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General Information
Symbol
Dmel\Rbp61
Species
D. melanogaster
Name
FlyBase ID
FBal0305169
Feature type
allele
Associated gene
Dmel\Rbp6
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Siddall et al., 2012)
Mutagen
FLPase
(Siddall et al., 2012)
Progenitor genotype
P{XP}d10465
(Siddall et al., 2012)
PBac{WH}f10793
(Siddall et al., 2012)
Cytology
Description

Deletion of the 3' half of the Rbp6 locus eliminating coding exons shared by all isoforms.

(Siddall et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rbp61/Rbp63 mutants are fertile. The number of germ cells in the males of this genotype is the same as in wild-type. No abnormalities are found in the number of germ cells present in germline cysts either. The only defect observed is the occasional mislocalisation of the somatic hub in 5 out of 20 testes analyzed. In each of these cases, a rosette of stem cells is observed around the irregularly localized hub cells, indicating that while the hub is no longer attached to the basal lamina, no loss of stem cells is ever observed.

      (Siddall et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      Rbp61 is a non-enhancer of male germline stem cell phenotype of msi2/msi1

      (Siddall et al., 2012)
      NOT Suppressor of
      Statement
      Reference

      Rbp61 is a non-suppressor of male germline stem cell phenotype of msi2/msi1

      (Siddall et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Rbp61
      (Siddall et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)