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FB2026_02
,
released June 18, 2026
MRE28, lincRNA.985
an ELAV family RNA binding protein that works as a post-transcriptional regulator - Fne is present in the cytoplasm of all neurons - promotes bypass of proximal polyadenylation signals in nascent transcripts - Lack of fne produces fusion of the mushroom body β-lobes and altered male courtship behaviour - Fne acquires a mini-exon, generating a new protein able to translocate to the nucleus and rescue ELAV-mediated alternative polyadenylation and alternative splicing
Please see the JBrowse view of Dmel\fne for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Multiple (sequential) stage-specific extensions of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
Gene model reviewed during 5.39
Gene model reviewed during 5.46
Gene model reviewed during 5.52
Gene model reviewed during 6.43
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fne using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: extended 3' UTR isoform
Isoforms of fne with extended 3' UTRs appear later in embryogenesis. Sequential, phased, 3' UTR lengthening is seen (3' UTR lengthening ocurring in multiple steps during later stages of embryogenesis).
JBrowse - Visual display of RNA-Seq signals
View Dmel\fne in JBrowse1-41
1-41.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
New stable cell line derived from S2-unspecified : S2 cells expressing fne or fne fused to the RNA editing enzyme Adar tagged with Tag:V5 under the control of the MT promoter were created.
New annotation (CR32646) in release 3 of the genome annotation.
Source for merge of: fne CG4396
Source for merge of: fne CR32646
Annotations CG4396 and CR32646 merged as CG4396 in release 5.2 of the genome annotation.
Source for identity of: BcDNA:HL02010 BcDNA:RE25290 CR32646
