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FB2026_01
,
released March 12, 2026
dADAR, EG:BACN35H14.1 , hypnos-2
double-stranded RNA adenosine deaminase - RNA editing enzyme that affects nervous system function, integrity, and behavior
Please see the JBrowse view of Dmel\Adar for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.49
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Shares 5' UTR with downstream gene.
Gene model reviewed during 5.41
Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
Gene model reviewed during 5.55
Gene model reviewed during 6.32
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Adar using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: extended 3' UTR isoform
Comment: shorter isoform
Comment: longer isoform
Isoforms of Adar with extended 3' UTRs appear later in embryogenesis.
Adar transcript is expressed throughout embryogenesis, with highest expression levels observed at 0-2 hours AEL and 8-12 hrs AEL. Expression levels are low during larval development, and the short isoforms exhibit another small peak during pupal stages. In situ analysis reveals that the short transcript isoforms are expressed primarily in pre-cellular stages, and in the gut endothelium from embryonic stage 16, in contrast to the more widespread pattern observed for the longer transcript isoforms.
Adar protein localizes to the nucleus, and is more concentrated in the nucleolus relative to the diffuse expression in the rest of the nucleus.
Adar long protein isoforms are expressed at all embryonic stages, at low levels during the third larval instar and early pupal stages, and higher levels in late pupal stages and in adult heads. The Adar short protein isoforms can be detected by Western blot only at the 0-2 and 12-16 hour AEL timepoints.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Adar in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
New stable cell line derived from S2-unspecified : S2 cells expressing fne or fne fused to the RNA editing enzyme Adar tagged with Tag:V5 under the control of the MT promoter were created.
New stable cell line derived from S2-unspecified : The S2 cell line was obtained from the laboratory of Catherine Rabouille. S2 cells were stably transfected with pMT-FMR1-Adarcd-V5.
A loss of Adar expression leads to defects in NMJ synaptic architecture.
Adar encodes the pre-mRNA editing enzyme for all reported A-to-I RNA editing sites in D.melanogaster.
Adults lacking Adar function are morphologically wild type, but show extreme behavioural deficits, including temperature-sensitive paralysis, locomotor uncoordination and tremors which increase in severity with age. Neurodegeneration accompanies the increase in phenotypic severity.
Adar undergoes developmentally regulated RNA editing that changes a conserved residue in the catalytic domain.
The genetic basis of anoxia tolerance is studied. 'hypnos' is the personification of sleep in Greek mythology.
Source for merge of: Adar hypnos-2
Source for merge of: Adar CG12598
Source for merge of Adar CG12598 was sequence comparison ( date:000423 ).
