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FB2025_04
,
released October 2, 2025
ms(3)100EF
RRM-containing domain - modifier of PEV promoting chromatin compaction and inactivation - controls cellular growth rate downstream of dMYC - transcriptional regulation by Modulo integrates meiosis and spermatid differentiation in male germ line - the nucleolar protein, Modulo, in complex with CAL1, is essential for the centromeric deposition of the centromere-specific histone H3 variant, CID
Please see the JBrowse view of Dmel\mod for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Gene model reviewed during 5.42
Gene model reviewed during 5.53
78 (kD)
The N-terminus is blocked.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mod using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: excluded from oogenesis stage S2
mod protein is most abundant in embryos but is detected at all developmental stages tested. It is first detected before cellularization in all somatic nuclei, precisely when pericentric heterochromatin becomes visible. After the first cell division, mod protein is found in lineages of specific embryonic primordia. These lineages arise from mitotic domains 1, 2, 4-6, 10, 13, 22, and 25.
JBrowse - Visual display of RNA-Seq signals
View Dmel\mod in JBrowse3-103
3-99.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
The size of the mod protein differs between testes and somatic tissues. The testes-specific mod variant has an apparent molecular mass that is consistent with the predicted 60.3 kDa of the full size protein. The mod variant expressed in somatic tissues has an apparent molecular mass of approximately 50 kDa and is missing the acidic N-terminal domain found in the full size protein.
Both the full-size testes-specific variant and the 50 kDa somatic variant of the mod protein specifically bind to the conserved testis-specific TSE promoter motif.
mod is required selectively in proliferative cells to sustain their growth and maintain their specific size.
mod gene acts downstream of pattern forming genes of both the embryonic axes and that its function is required for an accurate morphogenesis of several tissue types.
Postmeiotic differentiation defect.
mod is a haplo suppressor of position effect variegation (PEV). At the genetic level mod acts downstream of Ubx, Scr, tsh, dl, twi and sna. Mutant analysis demonstrates mod is required to allow accurate morphogenesis to occur. Together these results suggest that mod could act as a 'memory' of selector gene information regulating the expression of the gene directly involved in morphogenesis via chromatin structure.
Mutant phenotype, expression pattern during embryogenesis and DNA binding activity of gene product suggest that mod regulates chromatin structure and activity in specific cell lineages.
P element transformation experiments demonstrated that mod+ can replace the function of Map205.
Source for merge of: mod ms(3)100EF
"ird6" may correspond to the "krz" or "mod" gene or both; the ird61 mutation fails to complement the lethality of "krz" alleles (krzS047819) and deficiences which affect "mod" (Df(3R)A4-4L2 and Df(3R)A4-4L3).
"ird6" stated to correspond to "mod".
may be allelic to e(gs)
Source for identity of: mod CG2050
