Shun Li, J.S., Liu, Y., Kim, A.R., Qadiri, M., Xu, J., Xia, B., Binari, R., Asara, J.M., Hu, Y., Perrimon, N. (2025). The epigenetic factor Zrf1 regulates intestinal stem cell proliferation during midgut regeneration. PLoS Genet. 21(10): e1011910.
FlyBase ID
FBrf0263760
Publication Type
Research paper
Abstract
Stem cells are essential for tissue maintenance and regeneration, balancing self-renewal and differentiation to support homeostasis and repair. Through an RNAi screen in the Drosophila midgut, we identified the epigenetic factor Zrf1 as a critical regulator of intestinal stem cell (ISC) proliferation. Functional analyses reveal that Zrf1 integrates inputs from multiple signaling pathways and interacts with components of the RNA-induced silencing complex (RISC). Our findings suggest that Zrf1 is potentially a key chromatin regulator necessary for maintaining stem cell proliferation, enhancing our understanding of the molecular controls underlying stem cell function and chromatin-associated defects.
