FlyBase Allele Report: Dmel\N[HMS00009]

General Information

Symbol

Dmel\N^HMS00009

Species

D. melanogaster

Name

FlyBase ID

FBal0257057

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00009}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00009}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00009

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | adult stage, with Scer\GAL4^{Delta-05151-G}

(Zhao et al., 2022)

increased occurrence of cell division | adult stage, with Scer\GAL4^esg.PU

(Shun Li et al., 2025)

increased occurrence of cell division | larval stage, with Scer\GAL4^wor.PA

(Sood et al., 2022)

Phenotype Manifest In

adult midgut, with Scer\GAL4^esg.PU

(Shun Li et al., 2025)

enteroendocrine cell of posterior adult midgut epithelium | increased number, with Scer\GAL4^{Delta-05151-G}

(Zhao et al., 2022)

larval central brain, with Scer\GAL4^wor.PA

(Sood et al., 2022)

larval neuroblast, with Scer\GAL4^wor.PA

(Sood et al., 2022)

Detailed Description

Statement

Reference

The expression of N^HMS00009 under the control of Scer\GAL4^wor.PA results in larval central brain neuroblasts ectopically proliferating (i.e. increased numbers in S-phase), compared to controls.

(Sood et al., 2022)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

N^HMS00009, Scer\GAL4^esg.PU has increased occurrence of cell division | adult stage phenotype, suppressible by Zrf1^HMC05212, Scer\GAL4^esg.PU

(Shun Li et al., 2025)

Phenotype Manifest In

Suppressed by

Statement

Reference

N^HMS00009, Scer\GAL4^esg.PU has adult midgut phenotype, suppressible by Zrf1^HMC05212, Scer\GAL4^esg.PU

(Shun Li et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

33616

y¹ v¹; P{TRiP.HMS00009}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

N^HMS00009

(Panta et al., 2020)

N^RNAi1

(Blanco-Obregon et al., 2020)

N^RNAi

(Zhao et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

Open Close