FlyBase Allele Report: Dmel\fne[KK108902]

General Information

Symbol

Dmel\fne^KK108902

Species

D. melanogaster

Name

FlyBase ID

FBal0235912

Feature type

allele

Associated gene

Dmel\fne

Associated Insertion(s)

Carried in Construct

P{KK108902}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108902}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108902

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\MAPT^V337M.UAS

(Shulman et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | cell autonomous | larval stage, with Scer\GAL4^ppk.PG

(Alizzi et al., 2020)

Phenotype Manifest In

dendritic branch | cell autonomous | larval stage, with Scer\GAL4^ppk.PG

(Alizzi et al., 2020)

dendritic tree | cell autonomous | larval stage, with Scer\GAL4^ppk.PG

(Alizzi et al., 2020)

larval multidendritic class IV neuron | cell autonomous | larval stage, with Scer\GAL4^ppk.PG

(Alizzi et al., 2020)

Detailed Description

Statement

Reference

In individuals expressing fne^KK108902 under the control of Scer\GAL4^ppk.PG, L3 class IV da neurons show increased arbor empty space.

(Alizzi et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

fne^KK108902, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PU

(Shulman et al., 2011)

Other

Statement

Reference

Scer\GAL4^elav.PU, elav^JF03008, fne^KK108902 has lethal - all die before end of larval stage phenotype

(Zhang et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

fne^KK108902, Scer\GAL4^GMR.PU is a suppressor of eye | adult stage phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PU

(Shulman et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The moderate rough eye phenotype and reduced adult eye size characteristic for flies expressing Scer\GAL4^GMR.PU under the control of Hsap\MAPT^{V337M.Scer\UAS} is suppressed by co-expression of fne^KK108902, restoring a near wild-type phenotype.

(Shulman et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v101508

P{KK108902}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

fne^KK108902

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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