FlyBase Allele Report: Dmel\Hrb27C[k10413]

General Information

Symbol

Dmel\Hrb27C^k10413

Species

D. melanogaster

Name

FlyBase ID

FBal0044461

Feature type

allele

Associated gene

Dmel\Hrb27C

Associated Insertion(s)

P{lacW}Hrb27C^k10413

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Hammond et al., 1997)

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{lacW}Hrb27C^k10413

Cytology

Description

P{lacW} insertion 2.2kb from the Hrb27C coding sequence.

(Hammond et al., 1997)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage (with Hrb27C⁰²⁶⁴⁷)

(Bruckert et al., 2015)

abnormal neuroanatomy | adult stage (with Hrb27C^k16203)

(Bruckert et al., 2015)

lethal

(Goodrich et al., 2004)

lethal (with Hrb27C^5A2-6)

(Huynh et al., 2004)

lethal (with Hrb27C^7E7-18)

(Huynh et al., 2004)

lethal (with Hrb27C^10B2-9)

(Huynh et al., 2004)

lethal (with Hrb27C^EL2)

(Price et al., 2000)

lethal (with Hrb27C^k02814)

(Yano et al., 2004)

lethal | recessive

(Price et al., 2000)

partially lethal (with Hrb27C⁰²⁶⁴⁷)

(Bruckert et al., 2015)

partially lethal (with Hrb27C^k16203)

(Bruckert et al., 2015)

partially lethal - majority die

(Hammond et al., 1997)

partially lethal - majority die (with Hrb27C⁰²⁶⁴⁷)

(Yano et al., 2004)

partially lethal - majority die (with Hrb27C^k16203)

(Yano et al., 2004)

viable (with Hrb27C⁰²⁶⁴⁷)

(Price et al., 2000)

visible

(Hammond et al., 1997)

visible (with Hrb27C⁰²⁶⁴⁷)

(Price et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

Hrb27C^k10413/Hrb27C^k16203 transheterozygous flies frequently have Mushroom Bodies (MB) with α and β lobes of unequal width (asymmetric), truncated α lobes or MBs lacking either the α or the β lobes, when compared to controls. They also exhibit abnormal overextension of dorsal lobes when compared to controls.

Hrb27C^k10413/Hrb27C⁰²⁶⁴⁷ transheterozygous flies frequently have Mushroom Bodies (MB) with α and β lobes of unequal width (asymmetric), truncated α lobes or MBs lacking either the α or the β lobes when compared to controls. They also exhibit abnormal overextended αβ dorsal branches that systematically grow toward the midline when compared to controls.

(Bruckert et al., 2015)

<3% of eggs laid by Hrb27C¹⁰²⁸⁰/Hrb27C^k16203 or Hrb27C¹⁰²⁸⁰/Hrb27C^k10413 females exhibit any degree of dorsalisation.

(Goodrich et al., 2004)

Hrb27C^k10413/Hrb27C⁰²⁶⁴⁷ flies are viable but usually have small nicks in the wing margin.

(Price et al., 2000)

Small eye phenotype is observed in the majority of homozygous females, the posterior supraalar macrochaetae is missing in most males and females.

(Hammond et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Hrb27C¹⁰²⁸⁰/Hrb27C^k10413 is an enhancer of egg chorion phenotype of sqd¹/sqd^K12

(Goodrich et al., 2004)

Hrb27C¹⁰²⁸⁰/Hrb27C^k10413 is an enhancer of dorsal appendage phenotype of sqd¹/sqd^K12

(Goodrich et al., 2004)

Hrb27C¹⁰²⁸⁰/Hrb27C^k10413 is an enhancer of egg operculum phenotype of sqd¹/sqd^K12

(Goodrich et al., 2004)

Hrb27C¹⁰²⁸⁰/Hrb27C^k10413 is an enhancer of egg phenotype of sqd¹/sqd^K12

(Goodrich et al., 2004)

Other

Statement

Reference

Hrb27C¹⁰²⁸⁰/Hrb27C^k10413, sqd¹/sqd^K12 has nurse cell & nuclear chromosome phenotype

(Goodrich et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Dorsalisation of the eggs laid by sqd¹/sqd^K12 transheterozygotes is enhanced by Hrb27C¹⁰²⁸⁰/Hrb27C^k16203 so that 100% show some degree of dorsalisation.

(Goodrich et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Hrb27C^7E7-18

(Huynh et al., 2004)

Hrb27C^10B2-9

(Huynh et al., 2004)

Hrb27C^5A2-6

(Huynh et al., 2004)

Hrb27C^EL2

(Price et al., 2000)

Hrb27C⁰²⁶⁴⁷

(BDGP Project Members, 1994-1999)

Hrb27C^rF680

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

I. Kiss.

Comments

Complements: l(2)EL3^EL3. Complements: l(2)DL1^DL1.

(Price et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Hrb27C^k10413

hrp48⁵

(Hammond et al., 1997)

hrp48^k10413

(Bruckert et al., 2015)

l(2)02647^k10413

l(2)k10413

(Price et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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