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FB2026_02
,
released June 18, 2026
ssp4, l(2)k07433
microtubule minus-end-binding protein - organization of apical microtubule network to ensure size/shape homogeneity - links epithelial polarity to folding via a microtubule-based mechanical mechanism - interacts with and recruited by Shot stop which interacts with the cell cortex through its actin-binding domain - antagonist of microtubule depolymerizing kinesin Klp10A
Please see the JBrowse view of Dmel\Patronin for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.45
None of the polypeptides share 100% sequence identity.
Interacts with msps (PubMed:32066907). Associates with the minus end of the microtubules (PubMed:20946984).
The CKK domain binds microtubules.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Patronin using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\Patronin in JBrowse2-83
2-86.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
RNAi screen using dsRNA made from templates generated with primers directed against this gene in S2 cells causes pronounced microtubule severing in interphase cells. The severed microtubules often continue to grow at their minus ends, causing them to treadmill through the cytoplasm.
Source for merge of: CG33130 BcDNA:LD17191
Source for merge of: l(2)k07433 CG33130
Source for merge of: CG18459 CG18460
Source for merge of: CG18459 CG18462 CG6516
Annotations CG18459, CG18460, CG18462 and CG6516 merged as CG33130 in release 3 of the genome annotation.
Source for merge of CG33130 BcDNA:LD17191 was a shared cDNA ( date:030728 ).
Source for merge of CG18459 CG18460 was a shared cDNA ( date:010720 ).
Source for identity of: Patronin ssp4
Source for identity of: ssp4 l(2)k07433
The gene is named "Patronin" for the Latin "patronus" (protector), as it protects microtubule minus ends in vivo against depolymerization by Kinesin-13.
