Par-3, Par3, D-Par3, Bazooka/Par3, l(1)G0484
Gene model reviewed during 5.52
Gene model reviewed during 5.47
Gene model reviewed during 6.11
6.7 (northern blot)
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\baz using the Feature Mapper tool.
baz transcript is detected in early embryos and is expressed in a dynamic pattern during embryonic development. In gastrulating embryos, baz transcript is detected beneath the apical membrane in epithelial cells; later, a similar subcellular localization is detected in epithelial cells of the epidermis. In neuroblasts, expression is detected in a crest in the apical cytocortex (facing the epithelium).
cytoplasm | apical
baz protein is distributed diffusely in follicle stem cells, and is localized to the apical domain of downstream follicle cells.
In stage 13 embryos baz is expressed in Malpighian tubule Type II (stellate) cells, particularly those that contact the tubule lumen. All Malpighian tubule Type II cells contact the luminal surface of the tubules in mid stage 14 and express high levels of baz as well as crb, shg, and dlg1.
baz protein is detected at the apical cytocortex of epithelial cells such as the cells of the tracheal pit and epidermis. In neuroblasts, the protein is in a submembraneous crescent in the apical cytocortex. Expression is detected at metaphase but not at interphase.
colocalizes with par-6 and aPKC presynaptically, and with par-6 in the postsynaptic peribouton area.
GBrowse - Visual display of RNA-Seq signalsView Dmel\baz in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
baz is required for cell rearrangement and spatially regulated contractile behavior during axis elongation.
baz acts upstream of adherens junctions as epithelial polarity is established during cellularization.
baz acts as a permissive factor during cell invasion in the follicle cells. baz function is dispensable fro cell invasion and motility but is required cell-autonomously in mediating cell adhesion within the migrating border cell cluster.
baz is required for the establishment of apical-basal polarity in eye photoreceptors during early pupal stages.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells.
baz is likely to be part of a regulatory mechanism required to coordinate the axis of polarity of a cell with that of the embryo.
Embryos mutant for arm and sdt baz double mutant embryos have very similar early phenotypes with respect to zonula adherens formation. Results suggest that early stages in the assembly of the zonula adherens are critical for the stability of the polarised blastoderm epithelium.
A screen for X-linked genes that affect embryo morphology revealed baz.