FlyBase Gene Report: Dmel\CG43707

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG43707 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

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Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in Z disc

inferred from high throughput direct assay

(Sarov et al., 2016)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG43707 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG43707

View exonic expression by tissue for Dmel\CG43707

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33601/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263846

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263846

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31959

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG43707

Transgenic constructs containing regulatory region of CG43707

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

CG43707^GD10363

viable, with Scer\GAL4^tin.CΔ4

CG43707^GD10363

Other Phenotypes

Allele

flightless, with Scer\GAL4^Mef2.PR

CG43707^GD10363

Phenotype manifest in

Allele

indirect flight muscle cell, with Scer\GAL4^Mef2.PR

CG43707^GD10363

myofibril, with Scer\GAL4^Mef2.PR

CG43707^GD10363

sarcomere, with Scer\GAL4^Mef2.PR

CG43707^GD10363

Z disc, with Scer\GAL4^Mef2.PR

CG43707^GD10363

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (55)

Hsap\MPDZ

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\SYNJ2BP-COX16

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (46)

Rnor\RGD1560925

4 of 14

Yes

Rnor\Adap1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Rasgrf2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Tamalin

1 of 14

Rnor\Ush1c

1 of 14

Rnor\Whrn

1 of 14

Mus musculus (laboratory mouse) (46)

Mmus\Pdzph1

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Tamalin

1 of 14

Mmus\Ush1c

1 of 14

Mmus\Whrn

1 of 14

Xenopus tropicalis (Western clawed frog) (22)

Xtro\LOC116407614

3 of 13

Yes

Xtro\adcyap1r1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\mpdz

1 of 13

Xtro\plekha1

1 of 13

Yes

Xtro\plekha4

1 of 13

Xtro\plekhj1

1 of 13

Xtro\rasgrf2

1 of 13

Yes

Xtro\rgs18

1 of 13

Xtro\skap2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\XB5826631

1 of 13

Danio rerio (Zebrafish) (52)

Drer\pdzph1

5 of 14

Yes

Drer\whrna

2 of 14

Drer\adap2

1 of 14

Yes

Drer\arhgap24

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-234p6.5

1 of 14

Drer\si:dkey-191m6.4

1 of 14

Drer\si:dkey-276j7.2

1 of 14

Drer\skap2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\tamalin

1 of 14

Drer\ush1c

1 of 14

Drer\zgc:92360

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (19)

Cele\C46H11.6

1 of 14

Yes

Cele\C50F7.3

1 of 14

Yes

Cele\C52A11.3

1 of 14

Yes

Cele\cnt-2

1 of 14

Yes

Cele\F16G10.5

1 of 14

Yes

Cele\F20D6.1

1 of 14

Yes

Cele\F28E10.4

1 of 14

Yes

Cele\F40F9.3

1 of 14

Yes

Cele\gras-1

1 of 14

Yes

Cele\mics-1

1 of 14

Yes

Cele\mpz-4

1 of 14

Yes

Cele\smz-1

1 of 14

Yes

Cele\smz-2

1 of 14

Yes

Cele\stn-1

1 of 14

Yes

Cele\stn-2

1 of 14

Yes

Cele\T19B10.5

1 of 14

Yes

Cele\txt-1

1 of 14

Yes

Cele\Y37D8A.25

1 of 14

Yes

Cele\ZK849.1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (32)

Agam\AgaP_AGAP008221

6 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP012008

1 of 12

Arabidopsis thaliana (thale-cress) (4)

Atha\AGD1

1 of 13

Yes

Atha\AGD9

1 of 13

Yes

Atha\AT5G05710

1 of 13

Yes

Atha\PH1

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\BOI1

1 of 13

Yes

Scer\BOI2

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\ucp3

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG43707. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (32)

kmr

2 of 13

Syn1

2 of 13

1 of 13

baz

1 of 13

bbg

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Git

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0263846

MIST (protein-protein) - An integrated Molecular Interaction Database

33601

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VQU8

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-11

Cytogenetic map

24C3-24C3

Sequence location

2L:3,757,256..3,769,525 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

24C3-24C3

Limits computationally determined from genome sequence between P{EP}EP2595^EP2595 and P{lacW}ed^k01102

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-11

(FlyBase, 2016)

2-9.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

40211

y¹ w^*; Mi{MIC}CG43707^MI05137/SM6a

NIG-Fly

31959R-2

P{NIG.31959R}2

2LG-1520

y² VhaAC39-1^cho-1 v¹; P{U6-CG43707.NIG.sgRNA}attP40/CyO

VDRC

v102743

P{KK112326}VIE-260B

v318361

PBac{fTRG10018.sfGFP-FT}VK00033

v25847

w¹¹¹⁸; P{GD10363}v25847

v318445

PBac{fTRG00063.sfGFP-TVPTBF}VK00033

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (11)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH17694

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0263846

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG31959 CG31772

(FlyBase Genome Annotators, 2012)

Additional comments

Annotations CG31959 and CG31772 merged as CG43707 in release 5.43 of the genome annotation. Merge supported by RNA-seq junction and RNA-seq expression data.

(FlyBase Genome Annotators, 2012)

One of the introns of CG31772 has the sequence and structural characteristics of a "mirtron"- mirtrons are encoded as an intron of another gene which accumulate as a lariats after splicing and require debranching enzyme for conversion into a functional miRNA. The mirtron encoded by the CG31772 intron is mir-1004.

(Ruby et al., 2007)

Annotation CG10020 split into CG31959, CG31772 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG10020

CG31772

(Sarov et al., 2016, Hosono et al., 2015, Ashwal-Fluss et al., 2014, Jungreis et al., 2011, Ruby et al., 2007)

CG31959

(Japanese National Institute of Genetics, 2012.5.21, Keleman et al., 2009.8.5)

CG43707

(National Institute of Genetics Fly Stocks, 2022-, Aranjuez et al., 2012, FlyBase Genome Annotators, 2012, Rodriguez et al., 2012)

Name Synonyms

Secondary FlyBase IDs

FBgn0051959
FBgn0031569
FBgn0051772

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 56 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33601

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PC26

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PC26

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33601/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263846

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263846

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG43707

MARRVEL_MODEL - MARRVEL (model organism gene)

33601

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0263846

DroID - A comprehensive database of gene and protein interactions.

FBgn0263846

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0263846

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31959

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034046

MIST (protein-protein) - An integrated Molecular Interaction Database

33601

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VQU8

References (30)

The following external sites may use different assemblies or annotations than FlyBase.

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