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FB2026_01
,
released March 12, 2026
dlt, DPatj, discs lost
PDZ-domain junctional protein involved in assembling a protein complex that functions in planar cell polarity - Patj forms an apical protein complex with Crumbs and Stardust - plays supporting roles in apico-basal cell polarity and stability of adherens junction - involved in retinal morphogenesis, maintenance, and planar cell polarity.
Please see the JBrowse view of Dmel\Patj for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.46
Component of the SAC complex, a complex composed of crb, Patj and sdt. Interacts directly with nrx via its third and fourth PDZ domains. Interacts directly with par-6, possibly mediating a link between the SAC complex and the par-6 complex, which is composed of par-6, baz and aPKC.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Patj using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: anlage in statu nascendi
Patj protein is expressed in the neuroepithelium in the developing optic lobe. At the medial edge of the neuroepithelium, a subset of cells that express Patj but not dpn are identified as transitioning neuroepithelial cells. The cells immediately adjacent to these that lack expression of Patj are referred to as immature neuroblasts.
Patj is expressed in neurepithelial cells in the developing optic lobe.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Patj in JBrowse
3-1.0
3-2.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Df(3L)MY10 flies with rescue transgenes for Cdc37, α-Spec and dlt but not for Patj (Cdc37+t9.5, α-SpecUbi-p63E.PP and dltUbi-p63E.PP) have typical planar cell polarity defects in the eye, including misrotated ommatidia and R3/R3 symmetrical clusters.
FlyBase curator comment: The gene corresponding to genome annotation CG12021 was named " dlt:discs lost" in FBrf0107610. Subsequently the "dlt" phenotype was shown to map not to CG12021, but to the gene corresponding to genome annotation CG32315. Consequently the " dlt:discs lost" name was moved to CG32315, and the name of the gene for CG12021 was changed to "Patj". See Klaembt, 2003.10.31, personal communication to FlyBase.
Patj plays a crucial role in the polarisation of embryonic epithelia during cellular blastoderm formation.
Identification: Two hybrid screen with the cytoplasmic portion of Nrx-IV as a bait.
Mutations cause pupal lethality with third instar larvae devoid of imaginal discs.
Source for merge of: Patj CG12021
The "dre1/dlt" complementation group corresponds to the CG32315 gene and not to CG12021. It was previously reported in FBrf0107610 that the relevant locus for the "dre1" (dlt) complementation group was CG12021, based on mapping and complementation data (shown in Figure 4. of FBrf0107610). However, it has recently been shown (FBrf0167484) that "dre1" is allelic to CG32315 rather than CG12021. Re-evaluation of the "dre1" mutation indicates that the chromosome carries a T516S amino acid change in CG12021 and a stop codon at position 865 in CG32315. Since the mutation in CG12021 is conservative, it may not underlie the loss of imaginal discs observed in "dre1" mutants, and instead, the "dre1" mutant phenotypes described in FBrf0107610 are likely due to the mutation in CG32315. This is also supported by the observation that the P{PatjEHHS} construct (Figure 4 of FBrf0107610) now fails to rescue the "dre1" mutation. In addition, the "dre1" mutation fails to complement an allele in CG32315 ("Van04276"), clearly implicating CG32315 as causing the lethality associated with "dre1". It remains possible that the "dre1" phenotypes shown in Figure 6 of FBrf0107610 may result from a combination of mutations in both genes. Overexpression of CG12021 causes a severe loss of epithelial polarity as shown in Figure 7. of FBrf0107610. FlyBase curator comment: the T516S amino acid change in CG12021 on the "dre1" chromosome is represented by the allele Patjdre1 and the stop codon at position 865 in CG32315 on the "dre1" chromosome is represented by the allele dltdre1.
The dlt phenotype maps to the CG32315 annotation, not the CG12021 annotation, as was reported previously (FBrf0107610).
