The crumbs protein complex is one of the key regulators of apical cell polarity and cell shape, more specifically epithelial and photoreceptor cells. The core components of the crumbs complex are scaffolding proteins and recruit other polarity module proteins into close proximity. (Adapted from FBrf0239410 and FBrf0204878).
Notes on Group
crb binds and recruits Cdc42-PAR complex and re-enforces the molecular asymmetry created by the PAR complex (FBrf0238574).
