FlyBase Gene Report: Dmel\bbg

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bbg using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.31

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

hindgut anlage in statu nascendi

(Fisher et al., 2012)

posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 5

posterior endoderm anlage

(Kim et al., 2006)

embryonic stage 5 -- 6

mesectoderm

(Kearney et al., 2004)

embryonic stage 6 -- 10

dorsal ectoderm

(Kim et al., 2006)

embryonic stage 6 -- 12

posterior midgut primordium

(Kim et al., 2006)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

foregut anlage

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

mesectoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

mesectoderm anlage

(Kearney et al., 2004)

inclusive hindgut primordium

(Kim et al., 2006)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

mesectoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 9 -- 12

midline primordium

(Kearney et al., 2004)

anterior midgut primordium

(Kim et al., 2006)

hindgut proper primordium

(Kim et al., 2006)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

proventriculus primordium

(Fisher et al., 2012)

small intestine primordium

Comment: reported as small intestine specific anlage

(Fisher et al., 2012)

embryonic stage 11 -- 15

foregut primordium

(Kim et al., 2006)

embryonic stage 12 -- 15

small intestine primordium

(Kim et al., 2006)

embryonic stage 13

posterior spiracle primordium

(Kim et al., 2006)

embryonic stage 16 -- 17

embryonic/larval proventriculus

(Kim et al., 2006)

embryonic/larval pharynx

(Kim et al., 2006)

Keilin organ

(Kim et al., 2006)

mechanosensory sensory organ of embryonic abdominal segment

(Kim et al., 2006)

embryonic/larval posterior spiracle

(Kim et al., 2006)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

(Kim et al., 2006)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

ovary

(Aranjuez et al., 2012)

Additional Descriptive Data

During embryogenesis, bbg transcript is predominantly expressed in the developing gut. bbg transcript is first detected at embryonic stage 5, in the posterior endoderm anlage. bbg transcript is expressed in posterior midgut primordium by stage 6, in the invaginating hindgut primordium by stage 7, in the anterior midgut primordium at stages 9-10, and in the forgut primordium by stages 11-12. Gut expression is maintained though late embryogenesis, and becomes restricted to the pharynx and proventriculus at late embryonic stages. bbg transcript expression in the dorsal ectoderm begins at embryonic stage 6; this expression is restricted to the dorsal edge of the dorsal ectoderm by embryonic stage 9-10. In the wing disc, bbg transcript is expressed at the presumptive wing margin, and in a small stripe perpendicular to the wing margin in the dorsal wing pouch. bbg transcript is expressed at the dorsal-ventral compartment boundary of the haltere disc. bbg transcript is expressed in a pair of cell clusters near the center of the leg discs; at the medial side of the antennal disc; in a ring-shaped pattern in the larval optic lobe; and at and posterior to the morphogenetic furrow of the eye disc. bbg transcript expression exhibits isoform-specificity at embryonic and larval stages.

(Kim et al., 2006)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 6 -- 10

dorsal ectoderm

(Kim et al., 2006)

embryonic stage 6 -- 12

posterior midgut primordium

(Kim et al., 2006)

embryonic stage 7 -- 8

inclusive hindgut primordium

(Kim et al., 2006)

embryonic stage 9 -- 12

anterior midgut primordium

(Kim et al., 2006)

hindgut proper primordium

(Kim et al., 2006)

embryonic stage 11 -- 15

foregut primordium

(Kim et al., 2006)

embryonic stage 12 -- 15

small intestine primordium

(Kim et al., 2006)

embryonic stage 13

posterior spiracle primordium

(Kim et al., 2006)

embryonic stage 16 -- 17

embryonic/larval proventriculus

(Kim et al., 2006)

embryonic/larval pharynx

(Kim et al., 2006)

Keilin organ

(Kim et al., 2006)

mechanosensory sensory organ of embryonic abdominal segment

(Kim et al., 2006)

wandering third instar larval stage

presumptive wing margin

(Kim et al., 2006)

leg disc | distal

(Kim et al., 2006)

antennal disc | medial

(Kim et al., 2006)

eye disc posterior to the morphogenetic furrow

(Kim et al., 2006)

eye disc morphogenetic furrow

(Kim et al., 2006)

ommatidial precursor cluster

(Kim et al., 2006)

pupal stage P6 -- P7

eye photoreceptor cell

• apical plasma membrane

Comment: 30 hr APF

(Kim et al., 2006)

pupal stage P7 -- pharate adult stage P9

cone cell

• plasma membrane

Comment: 40-60 hr APF

(Kim et al., 2006)

pharate adult stage P8

interommatidial bristle

• plasma membrane

Comment: 50 hr APF

(Kim et al., 2006)

pharate adult stage P9

secondary pigment cell

• plasma membrane

Comment: 50 hr APF

(Kim et al., 2006)

tertiary pigment cell

• plasma membrane

Comment: 50 hr APF

(Kim et al., 2006)

adult stage

adult proventriculus

(Bonnay et al., 2013)

gut epithelium

(Bonnay et al., 2013)

adult midgut epithelium

(Bonnay et al., 2013)

oogenesis & adult stage | female

polar follicle cell

(Kim et al., 2006)

oocyte

• nucleus

(Kim et al., 2006)

adult stage | female & oogenesis stage S10

main body follicle cell

(Kim et al., 2006)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010, Dorus et al., 2006)

Additional Descriptive Data

bbg protein is localized to the apical and lateral sides of gut epithelial cells.

(Bonnay et al., 2013)

During oogenesis, bbg protein is expressed in the profollicular mesoderm, a layer of follicle cells that separates the germline cyst found at the posterior end of the germarium, from the anterior neighbouring younger cyst; strongly expressed in polar follicle cells; weakly expressed in somatic follicle cells surrounding early egg chambers; in follicle cells surrounding the oocyte; and in the oocyte nucleus. During embryogenesis, bbg protein is predominantly expressed in the developing gut. bbg protein is first detected at embryonic stage 6, in the posterior midgut primordium. bbg protein is expressed in the invaginating hindgut primordium by stage 7, in the anterior midgut primordium at stages 9-10, and in the forgut primordium by stages 11-12. Gut expression is maintained though late embryogenesis, and becomes restricted to the pharynx and proventriculus at late embryonic stages. bbg protein expression in the dorsal ectoderm begins at embryonic stage 6; this expression is restricted to the dorsal edge of the dorsal ectoderm by embryonic stage 9-10. In the wing disc, bbg protein is expressed at the presumptive wing margin, and in a similar pattern in the haltere disc. bbg protein is expressed in a pair of cell clusters near the center of the leg discs; at the medial side of the antennal disc; in a ring-shaped pattern in the larval optic lobe; and at and posterior to the morphogenetic furrow of the eye disc. During pupal eye development, bbg protein is also specifically and dynamically expressed in cone cells, mechanosensory bristle cells, and in secondary and tertiary pigment cells as each cell type becomes specified.

(Kim et al., 2006)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apical part of cell

inferred from direct assay

(Bonnay et al., 2013)

located_in nucleus

inferred from direct assay

(Kim et al., 2006)

located_in septate junction

inferred from direct assay

(Bonnay et al., 2013)

Expression Deduced from Reporters

Reporter: P{GawB}bbg^C96

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16 -- 17

abdominal sensory neuron

(Kim et al., 2006)

pharyngeal muscle cell

(Kim et al., 2006)

embryonic/larval salivary gland

(Kim et al., 2006)

mechanosensory neuron of embryonic/larval posterior spiracle

(Kim et al., 2006)

mechanosensory neuron of embryonic telson

(Kim et al., 2006)

larval stage

larval central nervous system

(Kim et al., 2006)

third instar larval stage

dorsal-ventral compartment boundary of the wing disc

(Usha and Shashidhara, 2010)

wandering third instar larval stage

presumptive wing margin

(Kim et al., 2006, Gustafson and Boulianne, 1996)

mechanosensory neuron of wing hinge primordium

(Kim et al., 2006)

dorsal-ventral compartment boundary of the haltere disc

(Kim et al., 2006)

eye disc posterior to the morphogenetic furrow

(Kim et al., 2006)

presumptive second segment of antenna | restricted

(Kim et al., 2006)

antennal disc | restricted

(Gustafson and Boulianne, 1996)

dorsal-ventral compartment boundary of the wing disc

(Srivastava and Bell, 2003)

oogenesis

polar follicle cell

Comment: early stages

(Aranjuez et al., 2012)

oogenesis stage S9 -- S10

border follicle cell

(Aranjuez et al., 2012)

follicle cell

(Aranjuez et al., 2012)

Reporter: P{ST.lexA::HG}bbg^DL-4

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

larval ventral nerve cord

(Bloomington Drosophila Stock Center, 2019)

larval central nervous system

(Bloomington Drosophila Stock Center, 2019)

embryonic/larval proventriculus

(Bloomington Drosophila Stock Center, 2019)

embryonic/larval salivary gland

(Bloomington Drosophila Stock Center, 2019)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\bbg in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\bbg

View exonic expression by tissue for Dmel\bbg

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0087007

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39583/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0087007

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0087007

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0087007

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9598

Flygut - An atlas of the Drosophila adult midgut

FBgn0087007

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\bbg

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 53 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of bbg

Transgenic constructs containing regulatory region of bbg

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6123

(Ryder, 2004.4.26)

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of larval stage | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

bbg^GD6101

Other Phenotypes

Allele

abnormal immune response | adult stage

bbg^B211

abnormal immune response | adult stage, with Scer\GAL4^esg.PU

bbg^GD6101

abnormal immune response | adult stage (with bbg^B211)

bbg^EY02818

abnormal immune response | adult stage (with bbg^EY02818)

bbg^B211

abnormal immune response | adult stage (with Df(3L)fz-GS1a)

bbg^EY02818

decreased fecundity, with Scer\GAL4^esg.PU

bbg^GD6101

increased mortality | conditional, with Scer\GAL4^esg.PU

bbg^GD6101

increased occurrence of cell division

bbg^B211

increased occurrence of cell division | adult stage

bbg^B211

short lived

bbg^B211

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

bbg^GD6101

some die during larval stage | recessive

Phenotype manifest in

Allele

adult midgut

bbg^B211

border follicle cell, with Scer\GAL4^c306

bbg^GD6101

imaginal disc

smooth septate junction

bbg^B211

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (34)

Hsap\PDZD2

3 of 14

Yes

Hsap\FRMPD2

2 of 14

Yes

Hsap\GRIP1

2 of 14

Hsap\IL16

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (32)

Rnor\Il16

3 of 14

Yes

Rnor\Pdzd2

3 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Tamalin

1 of 14

Rnor\Ush1c

1 of 14

Rnor\Whrn

1 of 14

Mus musculus (laboratory mouse) (34)

Mmus\Il16

3 of 14

Yes

Mmus\Pdzd2

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Gm20498

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Tamalin

1 of 14

Mmus\Ush1c

1 of 14

Mmus\Whrn

1 of 14

Xenopus tropicalis (Western clawed frog) (15)

Xtro\il16

2 of 13

Yes

Xtro\pdzd2

2 of 13

Yes

Xtro\adcyap1r1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (38)

Drer\si:dkey-92i15.4

4 of 14

Yes

Drer\il16

3 of 14

Yes

Drer\pdzd2

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\tamalin

1 of 14

Drer\ush1c

1 of 14

Drer\whrna

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (17)

Cele\mpz-1

2 of 14

Yes

Cele\C46H11.6

1 of 14

Yes

Cele\C50F7.3

1 of 14

Yes

Cele\C52A11.3

1 of 14

Cele\F16G10.5

1 of 14

Cele\F20D6.1

1 of 14

Yes

Cele\F28E10.4

1 of 14

Yes

Cele\F40F9.3

1 of 14

Yes

Cele\gras-1

1 of 14

Cele\mics-1

1 of 14

Cele\mpz-4

1 of 14

Yes

Cele\rhgf-1

1 of 14

Cele\smz-1

1 of 14

Yes

Cele\smz-2

1 of 14

Yes

Cele\T19B10.5

1 of 14

Yes

Cele\txt-1

1 of 14

Yes

Cele\ZK849.1

1 of 14

Anopheles gambiae (African malaria mosquito) (26)

Agam\AgaP_AGAP011384

8 of 12

Yes

Agam\AgaP_AGAP011385

7 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP012008

1 of 12

Agam\AgaP_AGAP012016

1 of 12

Yes

Agam\AgaP_AGAP012354

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:bbg. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (27)

loco

2 of 13

Patj

2 of 13

1 of 13

baz

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

cno

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

inflammatory bowel disease, tight/septate junction defect

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

bbg^EY02818

model of inflammatory bowel disease

CEA with bbg^B211

(Bonnay et al., 2013)

bbg^B211

model of inflammatory bowel disease

CEA

(Bonnay et al., 2013)

CEA with bbg^EY02818

(Bonnay et al., 2013)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

bbg^EY08296

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

bbg^EY21339

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PDZD2; PDZ domain containing 2

3 of 14

610697

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

bbg - cher

anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot

(Külshammer et al., 2022)

bbg - kst

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Forest et al., 2018)

bbg - sqh

anti tag coimmunoprecipitation, western blot

(Tsoumpekos et al., 2018)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

DCTN1-p150

enhanceable

bbg

(Chang et al., 2013)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0087007

MIST (protein-protein) - An integrated Molecular Interaction Database

39583

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q15K23

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-42

Cytogenetic map

70D7-70E1

Sequence location

3L:14,412,828..14,536,276 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

70D7-70E1

Limits computationally determined from genome sequence between P{PZ}l(3)70Da⁰²⁴⁰²&P{PZ}btl⁰⁰²⁰⁸ and P{PZ}Mpcp⁰⁰⁵⁶⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

70D-70D

(determined by in situ hybridisation)

(Kim and Boulianne, 1998)

Experimentally Determined Recombination Data

Location

3-42

(FlyBase, 2016)

3-36.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (30)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

43343

w^*; P{GawB}bbg^C96

99491

w^*; P{5'GawB}bbg^B211

84293

w^*; P{UAS-CC3Ai}2; P{GawB}bbg^C96

84334

w^*; P{UAS-VC3Ai}2; P{GawB}bbg^C96

36233

y¹ w^*; Mi{MIC}bbg^MI03323

37574

y¹ w^*; Mi{MIC}bbg^MI02392

11754

9598R-2

9598R-7

v101691

v15975

w¹¹¹⁸; P{GD6101}v15975

v318586

PBac{fTRG00527.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (63)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (48)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE18302

Other clones

MIP21057

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0087007

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

LP18027

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0087007

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Forest et al., 2018, Tsoumpekos et al., 2018)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: bbg CG9598 C96

(Kim et al., 2006)

Source for merge of: bbg CG9598

(FlyBase Genome Annotators, 2007)

Additional comments

Annotations CG9598 and CG9587 merged as CG42230 in release 5.5 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Nomenclature History

Source for database identify of

Source for identity of: bbg CG9587

(Kim et al., 2005.8.15)

Nomenclature comments

Etymology

The gene is named "big bang" based on the fact that the gene is quite large, and mutants all appear to be mildly bang-sensitive.

(Kim et al., 2006)

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

BBG

(Kim et al., 2005.8.15)

Bbg

(Watson et al., 2021)

C96

(Hall et al., 2004)

CG42230

(National Institute of Genetics Fly Stocks, 2023-, Bonnay et al., 2013, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2007)

CG9587

(Dorus et al., 2006, Kim et al., 2006)

CG9598

(Sarov et al., 2016, Japanese National Institute of Genetics, 2012.5.21, Peng et al., 2007, Kim et al., 2006)

Name Synonyms

C96

CG9587

CG9598

big bang

(Bonnay et al., 2013, Aranjuez et al., 2012, Fay et al., 2011, Kim et al., 2006)

Secondary FlyBase IDs

FBgn0036425
FBgn0036424
FBgn0024488
FBan0009598

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 101 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39583

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VUE8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VUE8

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0087007

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39583/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0087007

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0087007

FlyMine - An integrated database for Drosophila genomics

FBgn0087007

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG42230

MARRVEL_MODEL - MARRVEL (model organism gene)

39583

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0087007

DroID - A comprehensive database of gene and protein interactions.

FBgn0087007

DRSC - Results frm RNAi screens

FBgn0087007

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0087007

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0087007

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9598

Flygut - An atlas of the Drosophila adult midgut

FBgn0087007

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0087007

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010783

MIST (protein-protein) - An integrated Molecular Interaction Database

39583

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q15K23

References (79)

The following external sites may use different assemblies or annotations than FlyBase.

-0.31

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