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Citation
Usha, N., Shashidhara, L.S. (2010). Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila.  Dev. Biol. 341(2): 389--399.
FlyBase ID
FBrf0210647
Publication Type
Research paper
Abstract

Animal growth and development is dependent on reiterative use of key signaling pathways such as Hedgehog (Hh) pathway. It is widely believed that Cubitus-interruptus (Ci) mediates all functions of Hh pathway. Here we report that CG32062, the Drosophila homologue of Ataxin-2 Binding Protein 1 (dA2BP1), functions as a cofactor of Ci to specify intervein region between L3 and L4 veins of the adult wing. Specifically, Ci-mediated transactivation of knot/collier (kn) in this region of the developing wing imaginal disc is dependent on dA2BP1 function. Protein interaction studies and chromatin-immunoprecipiation experiments suggest that Ci helps dA2BP1 to bind kn promoter, which in turn may help Ci to activate kn expression. These results suggest a mechanism by which Ci may activate targets such as kn, which do not have classical Ci/Gli-binding sites.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Biol.
    Title
    Developmental Biology
    Publication Year
    1959-
    ISBN/ISSN
    0012-1606
    Data From Reference
    Alleles (30)
    Genes (20)
    Physical Interactions (4)
    Natural transposons (1)
    Insertions (8)
    Experimental Tools (1)
    Transgenic Constructs (22)
    Transcripts (7)