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Citation
de Vreede, G., Schoenfeld, J.D., Windler, S.L., Morrison, H., Lu, H., Bilder, D. (2014). The Scribble module regulates retromer-dependent endocytic trafficking during epithelial polarization.  Development 141(14): 2796--2802.
FlyBase ID
FBrf0225580
Publication Type
Research paper
Abstract

Scribble (Scrib) module proteins are major regulators of cell polarity, but how they influence membrane traffic is not known. Endocytosis is also a key regulator of polarity through roles that remain unclear. Here we link Scrib to a specific arm of the endocytic trafficking system. Drosophila mutants that block AP-2-dependent endocytosis share many phenotypes with Scrib module mutants, but Scrib module mutants show intact internalization and endolysosomal transport. However, defective traffic of retromer pathway cargo is seen, and retromer components show strong genetic interactions with the Scrib module. The Scrib module is required for proper retromer localization to endosomes and promotes appropriate cargo sorting into the retromer pathway via both aPKC-dependent and -independent mechanisms. We propose that the Scrib module regulates epithelial polarity by influencing endocytic itineraries of Crumbs and other retromer-dependent cargo.

PubMed ID
PubMed Central ID
PMC4197622 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Location data for crb[11A22] mutation.
Bilder, 2021.2.12, Location data for crb[11A22] mutation. [FBrf0248204]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference