FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AP-2α40-31
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General Information
Symbol
Dmel\AP-2α40-31
Species
D. melanogaster
Name
FlyBase ID
FBal0219035
Feature type
allele
Associated gene
Dmel\AP-2α
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Windler and Bilder, 2010)
Mutagen
ethyl methanesulfonate
(Windler and Bilder, 2010, Menut et al., 2007)
Progenitor genotype
Cytology
Description

Amino acid replacement: L510term.

(Windler and Bilder, 2010)

The premature stop codon is in the trunk region, prior to the hinge and appendage domains.

(Windler and Bilder, 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:410,854..410,854 [-]
Nucleotide change:

T410854G

Amino acid change:

L510term | AP-2alpha-PA; L522term | AP-2alpha-PB

Reported amino acid change:

L510term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Windler and Bilder, 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant eye discs (generated using the eyFLP-cell lethal system) show epithelial disorganisation accompanied by upregulated actin polymerisation and overgrowth.

      (Menut et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      AP-2alpha[+]/AP-2α40-31 is an enhancer of abnormal cell number | adult stage phenotype of PldUAS.cRa, Scer\GAL4pnr-MD237

      (Medina-Yáñez et al., 2020)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      AP-2alpha[+]/AP-2α40-31 is an enhancer of external sensory organ | adult stage phenotype of PldUAS.cRa, Scer\GAL4pnr-MD237

      (Medina-Yáñez et al., 2020)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      AP-2α40-31
      (Kong et al., 2025, Lin et al., 2015, de Vreede et al., 2014, Benhra et al., 2011, Windler and Bilder, 2010)
      Ap-2α40-31
      (Medina-Yáñez et al., 2020)
      MENE (2L)-A40-31
      (Menut et al., 2007)
      MENE(2L)-A40-31
      α-Adaptin40-31
      Name Synonyms
      Secondary FlyBase IDs
        References (7)