FlyBase Allele Report: Dmel\wts[UAS.cUa]

General Information

Symbol

Dmel\wts^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0319328

Feature type

allele

Associated gene

Dmel\wts

Associated Insertion(s)

Carried in Construct

P{UAS-wts.U}

Also Known As

UAS-wts

Key Links

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-wts.U}

Cytology

Description

UAS regulatory sequences drive expression of wts.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

wts

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Ptp61F^Δ, Ras85D^V12.cUa.UAS

(Liu et al., 2022)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Irwin et al., 2020)

ameliorates carcinoma

modeled by Ras85D^V12.UAS, msn³²⁰⁸

(Kong et al., 2021)

modeled by Csk^Q156Stop, Ras85D^V12.UAS

(Hirabayashi and Cagan, 2015)

modeled by Csk^Q156Stop, InR^A1325D.UAS, Ras85D^V12.UAS

(Hirabayashi and Cagan, 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^RapGAP1-OK6

(Sakuma et al., 2016)

abnormal size | adult stage, with Scer\GAL4^nub.PU

(Sansores-Garcia et al., 2011)

abnormal size | adult stage | RU486 conditional, with Scer\GAL4^GSG5966

(Lee et al., 2018)

abnormal size | larval stage, with Scer\GAL4^dpp.PU

(Sansores-Garcia et al., 2011)

decreased size | adult stage, with Scer\GAL4^bbg-C96

(Mok and Choi, 2022)

decreased size | adult stage, with Scer\GAL4^en-e16E

(Mok and Choi, 2022)

visible | adult stage, with Scer\GAL4^bbg-C96

(Mok and Choi, 2022)

visible | adult stage, with Scer\GAL4^en-e16E

(Mok and Choi, 2022)

visible | adult stage, with Scer\GAL4^GMR.PF

(Mok and Choi, 2022)

Phenotype Manifest In

adult midgut, with Scer\GAL4^GSG5966

(Lee et al., 2018)

adult midgut, with Scer\GAL4^hs.PB

(Lee et al., 2018)

autophagosome | adult stage, with Scer\GAL4^hs.PB

(Lee et al., 2018)

eye, with Scer\GAL4^GMR.PF

(Mok and Choi, 2022)

lipid droplet | adult stage, with Scer\GAL4^hs.PB

(Lee et al., 2018)

lipid droplet | adult stage | RU486 conditional, with Scer\GAL4^GSG5966

(Lee et al., 2018)

NMJ bouton | increased number, with Scer\GAL4^RapGAP1-OK6

(Sakuma et al., 2016)

wing, with Scer\GAL4^bbg-C96

(Mok and Choi, 2022)

wing, with Scer\GAL4^en-e16E

(Mok and Choi, 2022)

wing, with Scer\GAL4^nub.PU

(Sansores-Garcia et al., 2011)

wing disc, with Scer\GAL4^dpp.PU

(Sansores-Garcia et al., 2011)

wing margin, with Scer\GAL4^bbg-C96

(Mok and Choi, 2022)

Detailed Description

Statement

Reference

Expression of wts^UAS.cUa under the control of Scer\GAL4^GSG5966 (and RU486 feeding) leads to a significant decrease in lipid droplets (ie number, size and relative cellular content) in the adult midgut, as compared to controls.

The expression of wts^UAS.cUa under the control of Scer\GAL4^hs.PB and induced by shift to 29[o]C for 2 days before the experiment induces lipid droplet autophagy (dual LS2- and Atg8-positive puncta) in the adult midgut, as compared to controls.

(Lee et al., 2018)

Expression of wts^Scer\UAS.cUa under the control of Scer\GAL4^RapGAP1-OK6 results in a significantly increased number of satellite boutons on neuromuscular junctions in third instar larvae.

(Sakuma et al., 2016)

Expression of wts^{dsRNA.UAS.cUa} under the control of Scer\GAL4^dpp.PU causes slight undergrowth of the expressing region of the wing disc in the larva. Expression of wts^UAS.cUa under the control of Scer\GAL4^nub.PU causes a reduction in the size of the adult wing.

(Sansores-Garcia et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, wts^UAS.cUa has visible | adult stage phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.PF

(Mok and Choi, 2022)

Scer\GAL4^en-e16E, wts^UAS.cUa has visible | adult stage phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^en-e16E

(Mok and Choi, 2022)

Scer\GAL4^en-e16E, wts^UAS.cUa has decreased size | adult stage phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^en-e16E

(Mok and Choi, 2022)

Enhancer of

Statement

Reference

wts^UAS.cUa, Scer\GAL4^bbg-C96 is an enhancer of visible | adult stage phenotype of Mnat9^KK109382, Scer\GAL4^bbg-C96

(Mok and Choi, 2022)

Suppressor of

Statement

Reference

wts^UAS.cUa, Scer\GAL4^Act5C.PI is a suppressor of neoplasia | larval stage | somatic clone - tissue specific phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, msn³²⁰⁸

(Kong et al., 2021)

wts^UAS.cUa, Scer\GAL4^Act5C.PI is a suppressor of neoplasia | larval stage | somatic clone - tissue specific phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, bsk^DN.UAS.cUa, msn³²⁰⁸

(Kong et al., 2021)

Scer\GAL4^en.PU/wts^UAS.cUa is a suppressor of abnormal cell cycle | larval stage phenotype of Scer\GAL4^en.PU, Schip1^GS12074

(Chung et al., 2016)

Scer\GAL4^en.PU/wts^UAS.cUa is a suppressor of increased cell number | larval stage phenotype of Scer\GAL4^en.PU, Schip1^GS12074

(Chung et al., 2016)

Scer\GAL4^en.PU/wts^UAS.cUa is a suppressor of hyperplasia | adult stage phenotype of Scer\GAL4^en.PU, Schip1^GS12074

(Chung et al., 2016)

Scer\GAL4^dpp.PU/wts^UAS.cUa is a suppressor of neoplasia | larval stage phenotype of Scer\GAL4^dpp.PU, dia^{CA.UAS.Tag:HA}

(Sansores-Garcia et al., 2011)

Other

Statement

Reference

Scer\GAL4^Tub.PU, dachs¹/dachs^GC13, ft⁸/ft^G-rv, wts^UAS.cUa has abnormal planar polarity | adult stage phenotype

(Brittle et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, wts^UAS.cUa has eye phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.PF

(Mok and Choi, 2022)

Scer\GAL4^en-e16E, wts^UAS.cUa has wing phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^en-e16E

(Mok and Choi, 2022)

Enhancer of

Statement

Reference

wts^UAS.cUa, Scer\GAL4^bbg-C96 is an enhancer of wing margin phenotype of Mnat9^KK109382, Scer\GAL4^bbg-C96

(Mok and Choi, 2022)

Suppressor of

Statement

Reference

wts^UAS.cUa, Scer\GAL4^Act5C.PI is a suppressor of eye disc | somatic clone - tissue specific phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, bsk^DN.UAS.cUa, msn³²⁰⁸

(Kong et al., 2021)

wts^UAS.cUa, Scer\GAL4^Act5C.PI is a suppressor of eye disc | somatic clone - tissue specific phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, msn³²⁰⁸

(Kong et al., 2021)

Scer\GAL4^en.PU/wts^UAS.cUa is a suppressor of wing disc posterior compartment | larval stage phenotype of Scer\GAL4^en.PU, Schip1^GS12074

(Chung et al., 2016)

Scer\GAL4^en.PU/wts^UAS.cUa is a suppressor of wing blade phenotype of Scer\GAL4^en.PU, Schip1^GS12074

(Chung et al., 2016)

Scer\GAL4^dpp.PU/wts^UAS.cUa is a suppressor of wing disc phenotype of Scer\GAL4^dpp.PU, dia^{CA.UAS.Tag:HA}

(Sansores-Garcia et al., 2011)

Other

Statement

Reference

Scer\GAL4^Tub.PU, dachs¹/dachs^GC13, ft⁸/ft^G-rv, wts^UAS.cUa has ommatidium | adult stage phenotype

(Brittle et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of wts^Scer\UAS.cUa suppresses the over-proliferation effect in the larval wing disc and the increases in adult wing size caused by expression of Schip1^GS12074 driven by Scer\GAL4^en.PU.

(Chung et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

wts^Scer\UAS.cUa

wts^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

References (22)

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