FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Schip1GS12074
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General Information
Symbol
Dmel\Schip1GS12074
Species
D. melanogaster
Name
FlyBase ID
FBal0319324
Feature type
allele
Associated gene
Dmel\Schip1
Associated Insertion(s)
P{GSV6}Schip1GS12074
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GSV6}Schip1GS12074
    Cytology
    Description

    Insertion of a P{GSV6} element into the coding region of Schip1 (insertion is in the second exon). The level of Schip1 protein is strongly reduced when a Scer\GAL4-driver is used to drive expression from the Scer\UAS regulatory sequences present in the P{GSV6} element.

    (Chung et al., 2016)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GSV6}
    Regulatory region(s)
    UASt
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Schip1GS12074/Schip1GS12074 homozygotes are lethal during embryogenesis or an early larval stage. Schip1GS12074 driven by Scer\GAL4ey.PU alone does not significantly affect eye growth, but along with UAS-dicer2 leads to strong eye overgrowth with bulging. Expression of Schip1GS12074 driven in the posterior wing compartment by Scer\GAL4en.PU increases the number of mitotic cells in the posterior compartment of the wing disc (compared to the anterior control region). Scer\GAL4en.PU>Schip1GS12074 also leads to significant increases in adult wing blade size.

        (Chung et al., 2016)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressed by
        NOT suppressed by
        Statement
        Reference

        Scer\GAL4en.PU, Schip1GS12074 has wing blade phenotype, non-suppressible by Scer\GAL4en.PU/TaoKD.UAS.Tag:FLAG

        (Chung et al., 2016)
        Suppressor of
        Statement
        Reference

        Schip1GS12074/Scer\GAL4GMR.PU is a suppressor of eye phenotype of Scer\GAL4GMR.PU, exUAS.cUa

        (Chung et al., 2016)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Co-expression of wtsScer\UAS.cUa suppresses the over-proliferation effect in the larval wing disc and the increases in adult wing size caused by expression of Schip1GS12074 driven by Scer\GAL4en.PU. Co-expression of Schip1GS12074 suppresses the small eye phenotype in flies with expression of exScer\UAS.cUa driven by Scer\GAL4GMR.PU. Co-expression of TaoScer\UAS.P\T.T:Zzzz\FLAG (but not TaoKD.Scer\UAS.T:Zzzz\FLAG) suppresses wing changes in flies with Schip1GS12074 driven by Scer\GAL4en.PU.

        (Chung et al., 2016)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Schip1GS12074
        (Chung et al., 2016)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)