FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\wtsP2
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General Information
Symbol
Dmel\wtsP2
Species
D. melanogaster
Name
FlyBase ID
FBal0044496
Feature type
allele
Associated gene
Dmel\wts
Associated Insertion(s)
P{lacW}P2
P{lacW}P509-19
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Justice et al., 1995)
Progenitor genotype
P{lacW}P509-19
(Justice et al., 1995)
Associated Insertion(s)
P{lacW}P2
P{lacW}P509-19
Cytology
Description

Insertion of a second P{lacW} insertion, 38bp within the 5'-most exon.

(Justice et al., 1995)
Allele components
Component
Use(s)
Inserted element
P{lacW}
P{lacW}
Encoded product / tool
lacZ
lacZ
Tagged with
Tag:NLS(P)
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  cancer
      CEA
      (Justice et al., 1995)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The wing discs of wtsP2/Df(3R)Exel8194 mutants are overgrown compared to controls.

      (Gaspar et al., 2015)

      wtsP2 mutant eye clones show robust survival of extra pigment cells in the pupal retina at approximately 20 hours after pupal formation.

      (Verghese et al., 2012)

      wtsP2 heterozygotes do not show any abnormalities in wing vein patterning.

      (Dolezal et al., 2010)

      Hyperplastic overgrowth mutant. Apico-lateral junctional complexes appear normal.

      (Woods et al., 1997)

      wts tumour phenotype in mitotic clones: overproliferation and apical hypertrophy of epithelial cells leading to abnormal deposition of cuticle. Imaginal discs display remarkable hyperplasia of all imaginal discs and apical hypertrophy.

      (Justice et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      wtsP2/Df(3R)Exel8194 has wing disc | third instar larval stage phenotype, suppressible | partially by ZyxΔ41

      (Gaspar et al., 2015)
      Enhancer of
      Statement
      Reference

      wtsP2 is an enhancer of crossvein phenotype of Df(3R)A177der20/dcole88, dcoL39Q

      (Dolezal et al., 2010)

      wtsP2 is an enhancer of wing phenotype of Df(3R)A177der20/dcole88, dcoL39Q

      (Dolezal et al., 2010)
      Suppressor of
      Statement
      Reference

      wtsP2 is a suppressor | partially of wing phenotype of Klp10AUAS.cYa, Scer\GAL4en.PU

      (Yang and Choi, 2021)

      wtsP2 is a suppressor | partially of wing disc | larval stage phenotype of Klp10AUAS.cYa, Scer\GAL4en.PU

      (Yang and Choi, 2021)

      wts[+]/wtsP2 is a suppressor of wing phenotype of PatroninGD11946, Scer\GAL4en.PU

      (Yang and Choi, 2021)

      wts[+]/wtsP2 is a suppressor of wing disc | larval stage phenotype of PatroninGD11946, Scer\GAL4en.PU

      (Yang and Choi, 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The overgrowth of the wing discs characteristic for wtsP2/Df(3R)Exel8194 mutants can be partially suppressed by combination with ZyxΔ41/ZyxΔ41.

      (Gaspar et al., 2015)

      A wtsP2 heterozygous background significantly enhances the mild dominant wing crossvein defect seen in dcole88/Df(3R)A177der20 flies carrying dcot.L39Q. The extra vein fragment is present in more than 90% of the transheterozygotes. The fragment is usually enlarged, and most of the wings show additional extra vein material not present in either heterozygous combination. Wing size is also significantly increased in these flies.

      (Dolezal et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      References (22)