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Citation
Yu, T., Bachman, J., Lai, Z.C. (2013). Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer.  Genetics 195(3): 1193--1196.
FlyBase ID
FBrf0225171
Publication Type
Research paper
Abstract

The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.

PubMed ID
PubMed Central ID
PMC3813850 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference