FB2020_06, released Dec 22, 2020

Gene: Dmel\Dyrk2

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General Information
Symbol
Dmel\Dyrk2
Species
D. melanogaster
Name
Dual-specificity tyrosine phosphorylation-regulated kinase 2
Annotation Symbol
CG4551
Feature Type
protein_coding_gene
FlyBase ID
FBgn0016930
Gene Model Status
Current
Stock Availability
18 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

smi35A, dDYRK2, smell impaired 35A, DYRK, BG:DS01523.3

Key Links
Genomic Location
Cytogenetic map
35A1-35A2
Sequence location
2L:14,184,478..14,234,126 [-]
Recombination map

2-50

RefSeq locus
NT_033779 REGION:14184478..14234126
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables ATP binding
inferred from direct assay
(assigned by UniProt )
(Lochhead et al., 2003)
enables protein serine/threonine kinase activity
inferred from direct assay
(assigned by UniProt )
(Lochhead et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000624408
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in olfactory behavior
inferred from mutant phenotype
(Anholt et al., 1996)
involved_in positive regulation of Wnt signaling pathway
inferred from mutant phenotype
(Schertel et al., 2013)
involved_in protein phosphorylation
inferred from direct assay
(assigned by UniProt )
(Lochhead et al., 2003)
involved_in response to light stimulus
inferred from mutant phenotype
(Luebbering et al., 2013)
involved_in sensory perception of smell
inferred from mutant phenotype
(Luebbering et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in peptidyl-serine phosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN000624408
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in peptidyl-threonine phosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN000624408
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(assigned by UniProt )
(Lochhead et al., 2003)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000624546
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN000624546
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001173333
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. (Q9V3D5)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASES -
The DYRK (Dual-specificity tyrosine phosphorylation-regulated kinase) family kinases phosphorylate serine/threonine on other proteins (trans-phosphorylation), but can also autophosphorylate on tyrosine. Autophosphorylation within the activation loop occurs while still attached to the ribosome. (Adapted from PMID:15960979).
Protein Function (UniProtKB)
In vitro; can phosphorylate exogenous substrates on Ser and Thr residues. May have a physiological role in development being involved in cellular growth and differentiation.
(UniProt, Q9V3D5)
Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Dyrk2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Dyrk2-RA
FBtr0089288
NM_078840
4037
722
Dyrk2-RB
FBtr0089289
NM_205989
4677
722
Dyrk2-RC
FBtr0089290
NM_205988
4681
722
Dyrk2-RD
FBtr0100447
NM_001038817
4417
722
Dyrk2-RE
FBtr0100448
NM_001038818
4590
722
Dyrk2-RF
FBtr0329933
NM_001273526
4663
746
Dyrk2-RG
FBtr0336949
NM_001273527
2826
757
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Dyrk2-PA
FBpp0088344
79.6
722
9.21
NP_523564
AAF53380
Dyrk2-PB
FBpp0089218
79.6
722
9.21
NP_995711
AAS64705
Dyrk2-PC
FBpp0089219
79.6
722
9.21
NP_995710
AAS64706
Dyrk2-PD
FBpp0099869
79.6
722
9.21
NP_001033906
ABC65900
Dyrk2-PE
FBpp0099870
79.6
722
9.21
NP_001033907
ABC65901
Dyrk2-PF
FBpp0302965
82.5
746
9.42
NP_001260455
AGB92990
Dyrk2-PG
FBpp0307879
83.8
757
9.68
NP_001260456
AGB92991
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

722 aa isoforms: Dyrk2-PA, Dyrk2-PB, Dyrk2-PC, Dyrk2-PD, Dyrk2-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Post Translational Modification

Phosphorylated on serine/threonine residues.

(UniProt, Q9V3D5)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dyrk2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
central brain primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
visceral muscle primordium
(Fisher et al., 2012)
anterior midgut primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
somatic muscle primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic central brain neuron
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic/larval fat body
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
prothoracic gland
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval somatic muscle
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(assigned by UniProt )
(Lochhead et al., 2003)
Expression Deduced from Reporters
Reporter: Mi{Trojan-GAL4.un}Dyrk2MI12124-TG4.un
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | restricted
(Lee et al., 2018)
adult mushroom body
(Lee et al., 2018)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dyrk2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 22 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Dyrk2
Transgenic constructs containing regulatory region of Dyrk2
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with Df(2L)ED793)
viable (with Df(2L)ED8185)
viable (with Df(2L)ED8186)
Sterility
Allele
female semi-sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
fertile
Other Phenotypes
Allele
behavior defective | recessive
chemosensitive behavior defective
neurophysiology defective | adult stage
size defective, with Scer\GAL4GMR.PF
smell perception defective
smell perception defective | adult stage
visible, with Scer\GAL4Bx-MS1096
visible | recessive
Phenotype manifest in
Allele
cone cell | pupal stage | supernumerary, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4hs.2sev
interommatidial bristle | adult stage | ectopic, with Scer\GAL4GMR.PF
interommatidial bristle | adult stage | supernumerary, with Scer\GAL4GMR.PF
interommatidial bristle | ectopic | pupal stage, with Scer\GAL4GMR.PF
interommatidial bristle | pupal stage | supernumerary, with Scer\GAL4GMR.PF
ommatidium | adult stage, with Scer\GAL4GMR.PF
retina | pupal stage, with Scer\GAL4GMR.PF
secondary pigment cell | ectopic | pupal stage, with Scer\GAL4GMR.PF
secondary pigment cell | pupal stage | supernumerary, with Scer\GAL4GMR.PF
tertiary pigment cell | ectopic | pupal stage, with Scer\GAL4GMR.PF
tertiary pigment cell | pupal stage | supernumerary, with Scer\GAL4GMR.PF
wing, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (14)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\DYRK4
12 of 15
Yes
Yes
Hsap\DYRK2
6 of 15
No
No
Hsap\DYRK3
6 of 15
No
No
Hsap\DYRK1A
3 of 15
No
No
Hsap\DYRK1B
2 of 15
No
No
Hsap\HIPK1
2 of 15
No
No
Hsap\HIPK2
2 of 15
No
No
Hsap\HIPK3
2 of 15
No
No
Hsap\CLK1
1 of 15
No
No
Hsap\CLK2
1 of 15
No
No
4  
Hsap\CLK3
1 of 15
No
No
Hsap\CLK4
1 of 15
No
No
1  
Hsap\HIPK4
1 of 15
No
No
Hsap\PRPF4B
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (14)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Dyrk4
12 of 15
Yes
Yes
Mmus\Dyrk2
6 of 15
No
No
Mmus\Dyrk3
5 of 15
No
No
Mmus\Dyrk1a
3 of 15
No
No
Mmus\Dyrk1b
2 of 15
No
No
Mmus\Hipk1
2 of 15
No
No
Mmus\Hipk2
2 of 15
No
No
Mmus\Hipk3
2 of 15
No
No
Mmus\Clk1
1 of 15
No
No
Mmus\Clk2
1 of 15
No
No
1  
Mmus\Clk3
1 of 15
No
No
Mmus\Clk4
1 of 15
No
No
Mmus\Hipk4
1 of 15
No
No
Mmus\Prpf4b
1 of 15
No
No
Rattus norvegicus (Norway rat) (14)
Rnor\Dyrk2
5 of 13
Yes
No
Rnor\Dyrk4
5 of 13
Yes
Yes
Rnor\Dyrk3
3 of 13
No
No
Rnor\Dyrk1a
2 of 13
No
No
Rnor\Clk1
1 of 13
No
No
Rnor\Clk2
1 of 13
No
No
Rnor\Clk3
1 of 13
No
No
Rnor\Clk4
1 of 13
No
No
Rnor\Dyrk1b
1 of 13
No
No
Rnor\Hipk1
1 of 13
No
No
Rnor\Hipk2
1 of 13
No
No
Rnor\Hipk3
1 of 13
No
No
Rnor\Hipk4
1 of 13
No
No
Rnor\Prpf4b
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (10)
Xtro\dyrk2
3 of 12
Yes
No
Xtro\dyrk3
3 of 12
Yes
No
Xtro\dyrk1a
2 of 12
No
No
Xtro\hipk1
2 of 12
No
No
Xtro\hipk3
2 of 12
No
No
Xtro\clk1
1 of 12
No
No
Xtro\clk2
1 of 12
No
No
Xtro\clk3
1 of 12
No
No
Xtro\hipk2
1 of 12
No
No
Xtro\prpf4b
1 of 12
No
No
Danio rerio (Zebrafish) (16)
Drer\dyrk4
12 of 15
Yes
Yes
Drer\dyrk2
6 of 15
No
No
Drer\dyrk3
4 of 15
No
No
Drer\dyrk1b
2 of 15
No
No
Drer\hipk1a
2 of 15
No
No
Drer\hipk2
2 of 15
No
No
Drer\hipk3b
2 of 15
No
No
Drer\clk2a
1 of 15
No
No
Drer\clk2b
1 of 15
No
No
Drer\clk4a
1 of 15
No
No
Drer\clk4b
1 of 15
No
No
Drer\dyrk1aa
1 of 15
No
No
Drer\dyrk1ab
1 of 15
No
No
Drer\hipk3a
1 of 15
No
No
Drer\prpf4ba
1 of 15
No
No
Drer\si:ch211-160o17.4
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (11)
Cele\mbk-2
7 of 15
Yes
No
Cele\C36B7.1
3 of 15
No
Yes
Cele\mbk-1
3 of 15
No
No
Cele\C16A11.10
2 of 15
No
Yes
Cele\C36B7.2
2 of 15
No
Yes
Cele\hpk-1
2 of 15
No
No
Cele\prpf-4
2 of 15
No
No
Cele\Y73B3A.16
2 of 15
No
Yes
Cele\Y111B2A.1
2 of 15
No
No
Cele\gck-1
1 of 15
No
No
Cele\madd-3
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\AT1G13350
1 of 9
Yes
No
Atha\AT1G73450
1 of 9
Yes
Yes
Atha\AT3G53640
1 of 9
Yes
No
Atha\YAK1
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\YAK1
4 of 15
Yes
No
Scer\KNS1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\pom1
7 of 12
Yes
Yes
Spom\pom2
4 of 12
No
Yes
Spom\ppk15
2 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904V9 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000871
Drosophila simulans
Dsim\GD22014
Drosophila sechellia
Dsec\GM14885
Drosophila erecta
Dere\GG10156
Drosophila yakuba
Dyak\GE25082
Drosophila ananassae
Dana\GF15600
Drosophila pseudoobscura pseudoobscura
Dpse\GA18250
Drosophila persimilis
Dper\GL21056
Drosophila willistoni
Dwil\GK15100
Drosophila virilis
Dvir\GJ18062
Drosophila mojavensis
Dmoj\GI17385
Drosophila grimshawi
Dgri\GH10596
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503CV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012679
Musca domestica
House fly
Mdoa\17013063
Glossina morsitans
Tsetse fly
Gmor\GMOY006549
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02570
Mayetiola destructor
Hessian fly
Mdes\Mdes003638
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001504
Anopheles darlingi
American malaria mosquito
Adar\ADAC008949
Anopheles gambiae
Malaria mosquito
Agam\AGAP007847
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004687
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W034I )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004611
Bombyx mori
Silkmoth
Bmor\BGIBMGA006111
Danaus plexippus
Monarch butterfly
Dple\DPOGS215434-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS201564-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004717
Heliconius melpomene
Postman butterfly
Hmel\HMEL015837
Apis florea
Little honeybee
Aflo\2399304964
Apis florea
Little honeybee
Aflo\2293491844
Apis mellifera
Western honey bee
Amel\GB48589
Apis mellifera
Western honey bee
Amel\GB51445
Apis mellifera
Western honey bee
Amel\GB52508
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22707
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16428
Bombus terrestris
Buff-tailed bumblebee
Bter\15214582
Bombus terrestris
Buff-tailed bumblebee
Bter\15209190
Linepithema humile
Argentine ant
Lhum\LH15563
Linepithema humile
Argentine ant
Lhum\LH16480
Linepithema humile
Argentine ant
Lhum\LH16479
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002028
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002467
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG014340
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007499
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11370
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06730
Tribolium castaneum
Red flour beetle
Tcas\TC013573
Tribolium castaneum
Red flour beetle
Tcas\TC014135
Pediculus humanus
Human body louse
Phum\PHUM463810
Pediculus humanus
Human body louse
Phum\PHUM574200
Rhodnius prolixus
Kissing bug
Rpro\RPRC006548
Rhodnius prolixus
Kissing bug
Rpro\RPRC001740
Cimex lectularius
Bed bug
Clec\CLEC005496
Cimex lectularius
Bed bug
Clec\CLEC002884
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI073700
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03075
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11623
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0G88 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014657
Ixodes scapularis
Black-legged tick
Isca\ISCW018301
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68594.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM56935.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80615.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79592.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur12g03580
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g04070
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_51930
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_49628
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0Q46 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dyrk4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dyrk4_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dyrk2
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007679
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020453
Gallus gallus
Domestic chicken
Ggal\DYRK3
Gallus gallus
Domestic chicken
Ggal\DYRK2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Dyrk3
8 of 10
mnb
5 of 10
Hipk
4 of 10
Doa
2 of 10
Prp4k
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    DYRK4; dual specificity tyrosine phosphorylation regulated kinase 4
    12 of 15
    609181
        DYRK2; dual specificity tyrosine phosphorylation regulated kinase 2
        6 of 15
        603496
            DYRK3; dual specificity tyrosine phosphorylation regulated kinase 3
            6 of 15
            603497
                DYRK1A; dual specificity tyrosine phosphorylation regulated kinase 1A
                3 of 15
                600855
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
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                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                Dyrk2
                enzymatic study, western blot
                (Kinstrie et al., 2010, Kinstrie et al., 2006)
                Dyrk2 - Snr1
                anti tag coimmunoprecipitation, anti tag western blot, two hybrid, enzymatic study, western blot, autoradiography
                (Kinstrie et al., 2006)
                Dyrk2 - trx
                two hybrid, anti tag coimmunoprecipitation, anti tag western blot
                (Kinstrie et al., 2006)
                Summary of Genetic Interactions
                esyN Network Diagram
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                External Data
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                2L
                Recombination map

                2-50

                Cytogenetic map
                35A1-35A2
                Sequence location
                2L:14,184,478..14,234,126 [-]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                35A1-35A2
                Limits computationally determined from genome sequence between P{lacW}l(2)34Fak00811&P{PZ}wb09437 and P{EP}elBEP2039&P{PZ}osprJ571
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                35A1-35A2
                (determined by in situ hybridisation) 34F3--4 (determined by in situ hybridisation)
                (Ashburner et al., 1999)
                34F3-34F4
                (determined by in situ hybridisation)
                (Spradling et al., 1999)
                35A-35A
                (determined by in situ hybridisation)
                (Anholt et al., 1996)
                Experimentally Determined Recombination Data
                Location

                2-50

                (FlyBase, 2016)

                2-45.9

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (18)
                Genomic Clones (46)
                cDNA Clones (190)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of

                Source for identity of: smi35A CG4551

                (Kodira, 1999.11)
                Source for database merge of
                Additional comments

                The relationship between the "smi35A" mutation and the "DYRK2" transcription unit is unclear; the "smi35A" mutation was isolated in a P-element mutagenesis screen as a mutation with an olfaction defective phenotype and "DYRK2" was considered to be the protein product of "smi35A" based on the location of the P-element (P{lacW}smi35Ak11509) in the mutant line. However, the smell-impaired phenotype can be lost in P{lacW}smi35Ak11509 flies and P{lacW}smi35Ak11509 embryos show normal expression and tyrosine-phosphorylation of "DYRK2". Further analysis is therefore needed to demonstrate that the "smi35A" phenotype is attributable to the "DYRK2" gene.

                (Lochhead et al., 2003)
                Other Comments

                dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                (Kiger et al., 2003)

                Area matching Drosophila ESTs AA440852 and AA541034.

                (Davies, 2001.3.15)

                Identified during a screen for olfactory mutants.

                (Anholt et al., 1996)
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 74 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                FlyMine - An integrated database for Drosophila genomics
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Synonyms and Secondary IDs (12)
                Reported As
                Symbol Synonym
                BG:DS01523.3
                (Ashburner et al., 1999, Ashburner et al., 1999.10.12)
                CG4551
                (Neuert et al., 2017, Schertel et al., 2013, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Bhutkar et al., 2008, Molnar et al., 2006, Levis, 2003.3.14, Labourier et al., 2002, Morrison et al., 2000)
                DYRK
                (Ashburner, 2000, Morrison et al., 2000)
                DYRK2
                (Kinstrie et al., 2010, Cleghon, 1999.7.13)
                Dm2
                (Kinstrie et al., 2010)
                DmDyrk2
                (Luebbering et al., 2013)
                Dyrk2
                (Gene Disruption Project members, 2018-, Abruzzi et al., 2017, Neuert et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Sopko et al., 2014, Luebbering et al., 2013, Manning, 2001.10.15, Fedorowicz et al., 1999)
                dDYRK2
                (Kinstrie et al., 2006, Lochhead et al., 2003, Lochhead et al., 2003)
                smi35A
                (Bartok et al., 2015, Ashwal-Fluss et al., 2014, Toshima et al., 2014, Dogru and Palmer, 2013.4.24, Luebbering et al., 2013, Schertel et al., 2013, Schertel et al., 2013, Hazelett et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jungreis et al., 2011, Reis et al., 2010, Leatherbarrow and Halfon, 2009, Bhutkar et al., 2008, Beckstead et al., 2007, Morozova et al., 2007, Molnar et al., 2006, Pickersgill et al., 2006)
                Name Synonyms
                Dual specificity tyrosine phosphorylation-regulated kinase
                (Fedorowicz et al., 1999)
                Dual-specificity tyrosine phosphorylation-regulated kinase 2
                (Luebbering et al., 2013)
                smell impaired 35A
                (Morozova et al., 2007, Anholt et al., 1996)
                Secondary FlyBase IDs
                • FBgn0027884
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (88)