FlyBase Gene Report: Dmel\Dyrk2

General Information

Symbol

Dmel\Dyrk2

Species

D. melanogaster

Name

Dual-specificity tyrosine phosphorylation-regulated kinase 2

Annotation Symbol

CG4551

Feature Type

protein_coding_gene

FlyBase ID

FBgn0016930

Gene Model Status

Current

Stock Availability

17 publicly available

Gene Summary

In vitro; can phosphorylate exogenous substrates on Ser and Thr residues. May have a physiological role in development being involved in cellular growth and differentiation. (UniProt, Q9V3D5)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

smi35A, dDYRK2, DYRK, smell impaired 35A, BG:DS01523.3

Key Links

Genomic Location

Cytogenetic map

35A1-35A2

Sequence location

2L:14,184,478..14,234,126 [-]

Recombination map

2-50

RefSeq locus

NT_033779 REGION:14184478..14234126

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables ATP binding

inferred from direct assay

(assigned by UniProt )

(Lochhead et al., 2003)

enables protein serine/threonine kinase activity

inferred from direct assay

(assigned by UniProt )

(Lochhead et al., 2003)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000624408

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in olfactory behavior

inferred from mutant phenotype

(Anholt et al., 1996)

involved_in positive regulation of Wnt signaling pathway

inferred from mutant phenotype

(Schertel et al., 2013)

involved_in protein phosphorylation

inferred from direct assay

(assigned by UniProt )

(Lochhead et al., 2003)

involved_in response to light stimulus

inferred from mutant phenotype

(Luebbering et al., 2013)

involved_in sensory perception of smell

inferred from mutant phenotype

(Luebbering et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in peptidyl-serine phosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN000624408

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in peptidyl-threonine phosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN000624408

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(assigned by UniProt )

(Lochhead et al., 2003)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000624546

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in cytoskeleton

inferred from biological aspect of ancestor with PANTHER:PTN000624546

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN001173333

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. (Q9V3D5)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASES -: The DYRK (Dual-specificity tyrosine phosphorylation-regulated kinase) family kinases phosphorylate serine/threonine on other proteins (trans-phosphorylation), but can also autophosphorylate on tyrosine. Autophosphorylation within the activation loop occurs while still attached to the ribosome. (Adapted from PMID:15960979).

Protein Function (UniProtKB)

In vitro; can phosphorylate exogenous substrates on Ser and Thr residues. May have a physiological role in development being involved in cellular growth and differentiation.

(UniProt, Q9V3D5)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Dyrk2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V3D5)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dyrk2-RA

FBtr0089288

NM_078840

4037

722

Dyrk2-RB

FBtr0089289

NM_205989

4677

722

Dyrk2-RC

FBtr0089290

NM_205988

4681

722

Dyrk2-RD

FBtr0100447

NM_001038817

4417

722

Dyrk2-RE

FBtr0100448

NM_001038818

4590

722

Dyrk2-RF

FBtr0329933

NM_001273526

4663

746

Dyrk2-RG

FBtr0336949

NM_001273527

2826

757

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Dyrk2-PA

FBpp0088344

79.6

722

9.21

FBpp0089218

79.6

722

9.21

FBpp0089219

79.6

722

9.21

FBpp0099869

79.6

722

9.21

FBpp0099870

79.6

722

9.21

FBpp0302965

82.5

746

9.42

FBpp0307879

83.8

757

9.68

I0B8L2

NP_001260456

AGB92991

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

722 aa isoforms: Dyrk2-PA, Dyrk2-PB, Dyrk2-PC, Dyrk2-PD, Dyrk2-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Post Translational Modification

Phosphorylated on serine/threonine residues.

(UniProt, Q9V3D5)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dyrk2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dyrk2_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:

low

high

Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.

Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:

low

high

as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

central brain primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

anterior endoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(assigned by UniProt )

(Lochhead et al., 2003)

Expression Deduced from Reporters

Reporter: Mi{Trojan-GAL4.un}Dyrk2^{MI12124-TG4.un}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain | restricted

(Lee et al., 2018)

adult mushroom body

(Lee et al., 2018)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dyrk2 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dyrk2

View exonic expression by tissue for Dmel\Dyrk2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0016930

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34831/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0016930

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0016930

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0016930

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4551

Flygut - An atlas of the Drosophila adult midgut

FBgn0016930

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Dyrk2

Stages(s) 1-3
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 22 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dyrk2

Transgenic constructs containing regulatory region of Dyrk2

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2L)Exel8032

(Ryder, 2004.4.26)

Gene not disrupted in

Df(2L)b84h50

(BDGP Project Members, 1994-1999)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dyrk2^GD11347

viable, with Scer\GAL4^Mef2.PR

Dyrk2^GD11347

viable, with Scer\GAL4^pnr-MD237

Dyrk2^GD11347

viable, with Scer\GAL4^tin.CΔ4

Dyrk2^GD11347

viable (with Df(2L)ED793)

Dyrk2^MI04771

viable (with Df(2L)ED8185)

Dyrk2^MI04771

viable (with Df(2L)ED8186)

Dyrk2^MI04771

Sterility

Allele

female semi-sterile, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

Dyrk2^GL00313

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

fertile

Dyrk2^f04169

Other Phenotypes

Allele

abnormal behavior | recessive

Dyrk2¹

abnormal chemosensitive behavior

Dyrk2^k11509

abnormal neurophysiology | adult stage

Dyrk2^1w17

abnormal size, with Scer\GAL4^GMR.PF

Dyrk2^{WT.UAS.Tag:FLAG}

abnormal smell perception

Dyrk2¹

abnormal smell perception | adult stage

Dyrk2^1w17

visible, with Scer\GAL4^Bx-MS1096

Dyrk2^UAS.ORF

visible | recessive

Dyrk2^k11509

Phenotype manifest in

Allele

cone cell | pupal stage | increased number, with Scer\GAL4^GMR.PF

Dyrk2^{WT.UAS.Tag:FLAG}

eye, with Scer\GAL4^GMR.PF

Dyrk2^{WT.UAS.Tag:FLAG}

eye, with Scer\GAL4^hs.2sev

Dyrk2^{WT.UAS.Tag:FLAG}

interommatidial bristle | adult stage | ectopic, with Scer\GAL4^GMR.PF

Dyrk2^{WT.UAS.Tag:FLAG}

interommatidial bristle | adult stage | increased number, with Scer\GAL4^GMR.PF

Dyrk2^{WT.UAS.Tag:FLAG}

interommatidial bristle | ectopic | pupal stage, with Scer\GAL4^GMR.PF

Dyrk2^{WT.UAS.Tag:FLAG}

interommatidial bristle | pupal stage | increased number, with Scer\GAL4^GMR.PF

Dyrk2^{WT.UAS.Tag:FLAG}

ommatidium | adult stage, with Scer\GAL4^GMR.PF

Dyrk2^{WT.UAS.Tag:FLAG}

retina | pupal stage, with Scer\GAL4^GMR.PF

Dyrk2^{WT.UAS.Tag:FLAG}

secondary pigment cell | ectopic | pupal stage, with Scer\GAL4^GMR.PF

Dyrk2^{WT.UAS.Tag:FLAG}

secondary pigment cell | pupal stage | increased number, with Scer\GAL4^GMR.PF

Dyrk2^{WT.UAS.Tag:FLAG}

tertiary pigment cell | ectopic | pupal stage, with Scer\GAL4^GMR.PF

Dyrk2^{WT.UAS.Tag:FLAG}

tertiary pigment cell | pupal stage | increased number, with Scer\GAL4^GMR.PF

Dyrk2^{WT.UAS.Tag:FLAG}

wing, with Scer\GAL4^Bx-MS1096

Dyrk2^UAS.ORF

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\DYRK4

12 of 15

Yes

6 of 15

6 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Dyrk4

12 of 15

Yes

6 of 15

5 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (14)

Rnor\Dyrk2

5 of 13

Yes

Rnor\Dyrk4

5 of 13

Yes

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (10)

Xtro\dyrk2

3 of 12

Yes

Xtro\dyrk3

3 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (16)

Drer\dyrk4

12 of 15

Yes

6 of 15

4 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:ch211-160o17.4

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (11)

Cele\mbk-2

7 of 15

Yes

Cele\C36B7.1

3 of 15

Yes

Cele\mbk-1

3 of 15

Cele\C16A11.10

2 of 15

Yes

Cele\C36B7.2

2 of 15

Yes

Cele\hpk-1

2 of 15

Cele\prpf-4

2 of 15

Cele\Y73B3A.16

2 of 15

Yes

Cele\Y111B2A.1

2 of 15

Cele\gck-1

1 of 15

Cele\madd-3

1 of 15

Arabidopsis thaliana (thale-cress) (4)

Atha\AT1G13350

1 of 9

Yes

Atha\AT1G73450

1 of 9

Yes

Atha\AT3G53640

1 of 9

Yes

Atha\YAK1

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\YAK1

4 of 15

Yes

Scer\KNS1

1 of 15

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\pom1

7 of 12

Yes

Spom\pom2

4 of 12

Yes

Spom\ppk15

2 of 12

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (5)

Gene Symbol

Score

Source

Alignment

8 of 10

mnb

5 of 10

Hipk

4 of 10

Doa

2 of 10

Prp4k

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DYRK4; dual specificity tyrosine phosphorylation regulated kinase 4

12 of 15

609181

DYRK2; dual specificity tyrosine phosphorylation regulated kinase 2

6 of 15

603496

DYRK3; dual specificity tyrosine phosphorylation regulated kinase 3

6 of 15

603497

DYRK1A; dual specificity tyrosine phosphorylation regulated kinase 1A

3 of 15

600855

INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL DOMINANT 7; MRD7

autosomal dominant non-syndromic intellectual disability 7

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Dyrk2

enzymatic study, western blot

(Kinstrie et al., 2010, Kinstrie et al., 2006)

Dyrk2 - Snr1

anti tag coimmunoprecipitation, anti tag western blot, enzymatic study, western blot, two hybrid, autoradiography

(Kinstrie et al., 2006)

Dyrk2 - trx

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Kinstrie et al., 2006)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0016930

MIST (protein-protein) - An integrated Molecular Interaction Database

Dyrk2

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-50

Cytogenetic map

35A1-35A2

Sequence location

2L:14,184,478..14,234,126 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

35A1-35A2

Limits computationally determined from genome sequence between P{lacW}l(2)34Fa^k00811&P{PZ}wb⁰⁹⁴³⁷ and P{EP}elB^EP2039&P{PZ}osp^rJ571

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

35A1-35A2

(determined by in situ hybridisation) 34F3--4 (determined by in situ hybridisation)

(Ashburner et al., 1999)

34F3-34F4

(determined by in situ hybridisation)

(Spradling et al., 1999)

35A-35A

(determined by in situ hybridisation)

(Anholt et al., 1996)

Experimentally Determined Recombination Data

Location

2-50

(FlyBase, 2016)

2-45.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

30478

P{lArB}Dyrk2¹; ry⁵⁰⁶

18737

w¹¹¹⁸; PBac{WH}Dyrk2^f04169

63730

w¹¹¹⁸; PBac{IT.GAL4}Dyrk2^0646-G4

65658

w¹¹¹⁸; PBac{IT.GAL4}Dyrk2^1301-G4

56850

y¹ w^*; Mi{MIC}Dyrk2^MI12124

38165

y¹ w^*; Mi{MIC}Dyrk2^MI04771/SM6a

35393

y¹ sc^* v¹ sev²¹; P{TRiP.GL00313}attP2

41626

y¹ sc^* v¹ sev²¹; P{TRiP.GL01208}attP2

FlyORF

F001642

M{UAS-smi35A.ORF}ZH-86Fb

VDRC

v101376

P{KK108832}VIE-260B

v40535

w¹¹¹⁸; P{GD11347}v40535

v341217

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00251}attP40/CyO-GFP

More stocks available...

Genomic Clones (46)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (190)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP35018

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0016930

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0016930

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34831

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: smi35A CG4551

(Kodira, 1999.11)

Source for database merge of

Additional comments

The relationship between the "smi35A" mutation and the "DYRK2" transcription unit is unclear; the "smi35A" mutation was isolated in a P-element mutagenesis screen as a mutation with an olfaction defective phenotype and "DYRK2" was considered to be the protein product of "smi35A" based on the location of the P-element (P{lacW}smi35A^k11509) in the mutant line. However, the smell-impaired phenotype can be lost in P{lacW}smi35A^k11509 flies and P{lacW}smi35A^k11509 embryos show normal expression and tyrosine-phosphorylation of "DYRK2". Further analysis is therefore needed to demonstrate that the "smi35A" phenotype is attributable to the "DYRK2" gene.

(Lochhead et al., 2003)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Area matching Drosophila ESTs AA440852 and AA541034.

(Davies, 2001.3.15)

Identified during a screen for olfactory mutants.

(Anholt et al., 1996)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 78 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34831

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V3D5

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V3D5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V3D5

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0016930

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0016930

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34831/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0016930

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dyrk2_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0016930

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0016930

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4551

Flygut - An atlas of the Drosophila adult midgut

FBgn0016930

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34831

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014135

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4551

MARRVEL_MODEL - MARRVEL (model organism gene)

34831

modMine - A data warehouse for the modENCODE project

FBgn0016930

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9V3D5

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0016930

DRSC - Results frm RNAi screens

FBgn0016930

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0016930

FlyMine - An integrated database for Drosophila genomics

FBgn0016930

MIST (protein-protein) - An integrated Molecular Interaction Database

Dyrk2

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

BG:DS01523.3

(Ashburner et al., 1999, Ashburner et al., 1999.10.12)

CG4551

(Neuert et al., 2017, Schertel et al., 2013, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Bhutkar et al., 2008, Molnar et al., 2006, Levis, 2003.3.14, Labourier et al., 2002, Morrison et al., 2000)

DYRK

(Ashburner, 2000, Morrison et al., 2000)

DYRK2

(Kinstrie et al., 2010, Cleghon, 1999.7.13)

Dm2

(Kinstrie et al., 2010)

DmDyrk2

(Luebbering et al., 2013)

Dyrk2

(Pang et al., 2021, Gene Disruption Project members, 2018-, Abruzzi et al., 2017, Neuert et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Sopko et al., 2014, Luebbering et al., 2013, Manning, 2001.10.15, Fedorowicz et al., 1999)

dDYRK2

(Kinstrie et al., 2006, Lochhead et al., 2003, Lochhead et al., 2003)

smi35A

(Kitatani et al., 2020, Bartok et al., 2015, Ashwal-Fluss et al., 2014, Toshima et al., 2014, Dogru and Palmer, 2013.4.24, Luebbering et al., 2013, Schertel et al., 2013, Schertel et al., 2013, Hazelett et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jungreis et al., 2011, Reis et al., 2010, Leatherbarrow and Halfon, 2009, Bhutkar et al., 2008, Beckstead et al., 2007, Morozova et al., 2007, Molnar et al., 2006, Pickersgill et al., 2006)

Name Synonyms

Dual specificity tyrosine phosphorylation-regulated kinase

(Fedorowicz et al., 1999)

Dual-specificity tyrosine phosphorylation-regulated kinase 2

(Luebbering et al., 2013)

smell impaired 35A

(Morozova et al., 2007, Anholt et al., 1996)

Secondary FlyBase IDs

FBgn0027884

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

References (90)

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