FlyBase Gene Report: Dmel\p38c

General Information

Symbol

Dmel\p38c

Species

D. melanogaster

Name

p38c MAP kinase

Annotation Symbol

CG33338

Feature Type

protein_coding_gene

FlyBase ID

FBgn0267339

Gene Model Status

Current

Stock Availability

9 publicly available

Enzyme Name (EC)

mitogen-activated protein kinase (2.7.11.24)

Gene Summary

p38c MAP kinase (p38c) encodes a protein involved in the stress and wound responses, regulating the expression of Duox and Ddc. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

p38, Mpk2B

Key Links

Genomic Location

Cytogenetic map

95E5-95E5

Sequence location

3R:24,149,020..24,150,203 [-]

Recombination map

3-83

RefSeq locus

NT_033777 REGION:24149020..24150203

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables MAP kinase activity

inferred from direct assay

(Chakrabarti et al., 2014)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR003527, InterPro:IPR017441

(InterPro Project Members, 2004-)

enables MAP kinase activity

inferred from electronic annotation with InterPro:IPR003527

(InterPro Project Members, 2004-)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719

(InterPro Project Members, 2004-)

enables protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in p38MAPK cascade

inferred from mutant phenotype

(Chakrabarti et al., 2014)

involved_in regulation of adult chitin-containing cuticle pigmentation

inferred from genetic interaction with FLYBASE:Ask1; FB:FBgn0014006

(Sekine et al., 2011)

involved_in regulation of lipid storage

inferred from mutant phenotype

(Chakrabarti et al., 2014)

involved_in regulation of response to oxidative stress

inferred from mutant phenotype

(Chakrabarti et al., 2014)

involved_in response to bacterium

inferred from mutant phenotype

(Chakrabarti et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in intracellular signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Chakrabarti et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CONVENTIONAL MITOGEN ACTIVATED PROTEIN KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (P83100)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

MAP kinase activity

(1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) (2.7.11.24)

(2) L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) (2.7.11.24)

protein serine/threonine kinase activity

Summaries

Gene Snapshot

p38c MAP kinase (p38c) encodes a protein involved in the stress and wound responses, regulating the expression of Duox and Ddc. [Date last reviewed: 2019-03-14]

Gene Group (FlyBase)

CONVENTIONAL MITOGEN ACTIVATED PROTEIN KINASES -: Conventional Mitogen-activated protein kinases (MAPK) are proline-directed protein serine/threonine kinases that are components of the MAPK signaling cascade. MAPKs are activated by dual phosphorylation on Thr and Tyr residues within a conserved Thr-X-Tyr motif located in the activation loop by MAPK kinases. (Adapted from PMID:21372320).

Protein Function (UniProtKB)

Kinase involved in a signal transduction pathway.

(UniProt, P83100)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\p38c for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P83100)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

p38c-RA

FBtr0084582

NM_206554

1184

356

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

p38c-PA

FBpp0083967

42.0

356

7.29

P83100

NP_996277

AAS65203

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Post Translational Modification

The phosphorylation on Thr-177 activates the enzyme (By similarity). A conserved Tyr, which must also be phosphorylated to activate the enzyme in closely related sequences, is replaced by His-179 in this sequence.

(UniProt, P83100)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P83100

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\p38c using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

p38c_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.33

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Chakrabarti et al., 2014)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\p38c in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\p38c

View exonic expression by tissue for Dmel\p38c

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0267339

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

2768679/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0267339

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0046322

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0267339

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of p38c

Transgenic constructs containing regulatory region of p38c

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene partially disrupted in

Df(3R)p38a-c^del

(Chen et al., 2010)

Gene disrupted in

Df(3R)crb-F89-4

(Martin-Blanco and Martinez Arias, 1997)

Df(3R)p38c⁷

(Chen et al., 2010)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Sterility

Allele

female fertile

female sterile

male fertile

Other Phenotypes

Allele

abnormal immune response

p38c^7B1

abnormal immune response, with Scer\GAL4^NP0001

p38c^UAS.cCa

abnormal oxidative stress response

p38c^7B1

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (50)

Hsap\MAPK13

6 of 14

Yes

5 of 14

5 of 14

5 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ULK1

1 of 14

Hsap\ULK2

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (28)

Rnor\Mapk13

6 of 14

Yes

5 of 14

5 of 14

5 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Ulk1

1 of 14

Rnor\Ulk2

1 of 14

Mus musculus (laboratory mouse) (26)

Mmus\Mapk11

5 of 14

Yes

Mmus\Mapk13

5 of 14

Yes

Mmus\Mapk14

5 of 14

Yes

4 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Ulk1

1 of 14

Mmus\Ulk2

1 of 14

Xenopus tropicalis (Western clawed frog) (27)

Xtro\mapk13

4 of 13

Yes

Xtro\XB956263

4 of 13

Yes

3 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (33)

Drer\mapk13

6 of 14

Yes

Drer\zgc:171775

6 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-45c16.2

1 of 14

Drer\srpk1a

1 of 14

Drer\stk36

1 of 14

Drer\uhmk1

1 of 14

Yes

Drer\ulk1a

1 of 14

Drer\ulk1b

1 of 14

Drer\ulk2

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (23)

Cele\pmk-1

5 of 14

Yes

Cele\pmk-2

4 of 14

Cele\pmk-3

3 of 14

Yes

Cele\C49C3.10

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (18)

Agam\AgaP_AGAP009207

3 of 12

Yes

Agam\AgaP_AGAP012148

3 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (49)

Atha\ATMPK13

3 of 13

Yes

Atha\MPK1

3 of 13

Yes

Atha\MPK2

3 of 13

Yes

Atha\MPK3

3 of 13

Yes

Atha\MPK4

3 of 13

Yes

Atha\MPK5

3 of 13

Yes

Atha\MPK6

3 of 13

Yes

Atha\MPK7

3 of 13

Yes

Atha\MPK10

3 of 13

Yes

Atha\MPK11

3 of 13

Yes

Atha\MPK12

3 of 13

Yes

Atha\MPK14

3 of 13

Yes

Atha\AT4G01595

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (11)

Scer\HOG1

6 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\sty1

4 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:p38c. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (25)

p38a

7 of 13

p38b

7 of 13

6 of 13

bsk

4 of 13

Erk7

4 of 13

nmo

4 of 13

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Doa

1 of 13

Dyrk2

1 of 13

Dyrk3

1 of 13

Hipk

1 of 13

mnb

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

wnd

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MAPK13; mitogen-activated protein kinase 13

6 of 14

602899

MAPK11; mitogen-activated protein kinase 11

5 of 14

602898

MAPK12; mitogen-activated protein kinase 12

5 of 14

602399

MAPK14; mitogen-activated protein kinase 14

5 of 14

600289

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

p38c - CG2852

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - CG31800

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - CG5721

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - CG7518

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - CG8360

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - CG9372

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - Ciz1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - Dlg5

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - Hou

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - Npl4

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - P32

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - P58IPK

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - Rab1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - Rbsn-5

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - Rex2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - RfC3

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - Spf30

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - Tmem214

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - dpa

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - holn1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - mbo

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - ps

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - rad50

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - shi

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - ush

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

p38c - βTub97EF

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Ask1

suppressible

p38c

(Sekine et al., 2011)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0267339

MIST (protein-protein) - An integrated Molecular Interaction Database

2768679

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-83

Cytogenetic map

95E5-95E5

Sequence location

3R:24,149,020..24,150,203 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

95E5-95E5

Limits computationally determined from genome sequence between P{PZ}Syx1A⁰⁶⁷³⁷&P{PZ}Syx1A¹⁰⁶⁶⁰ and P{PZ}crb⁰⁷²⁰⁷&P{PZ}BRWD3⁰⁵⁸⁴² 95E5

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

91E1-91E2

(Manning, 2001.10.11)

Experimentally Determined Recombination Data

Location

3-83

(FlyBase, 2016)

3-82.7

(Comeron et al., 2012)

(Martin-Blanco and Martinez Arias, 1997)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

40970

w^*; p38c^1A1/TM6

40967

w^*; p38c^19B1/TM6

602378

y¹ w¹; P{TKO-UAS.GS06186}attP40/CyO

603473

y¹ w¹; P{TKO-UAS.GS06231}attP40/CyO

83558

y¹ sc^* v¹ sev²¹; P{TKO.GS04345}attP40

14126

y¹ w^67c23; ry⁵⁰⁶ P{SUPor-P}p38c^KG05834

64846

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05719}attP2

11024

v105173

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (9)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0267339

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Chakrabarti et al., 2014)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG33338) in release 3.2 of the genome annotation.

(FlyBase Genome Annotators, 2004)

An MAPK protein, it is very unusual in that it lacks a MAPKK phosphorylation site.

(Martin-Blanco and Martinez Arias, 1997)

Relationship to Other Genes

Source for database merge of

Source for merge of: p38c Mpk2B

(FlyBase, 1992-)

Additional comments

The p38c gene may have been derived from the p38a gene, but as the region of similarity between the two genes does not span an exon-exon junction in the parental gene, retroposition cannot necessarily be inferred.

(Zhang et al., 2011)

It's clear from the text of the sole reference associated with 'Mpk2B' (FBrf0092159, an ADRC abstract) that it is identical to 'p38c'.

(FlyBase, 1992-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG33338

(Chen et al., 2012, Zhang et al., 2011, Zhang et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Davis et al., 2008)

Dp38c

(Sekine et al., 2011)

Mpk2B

P38

(El Chamy et al., 2015)

P38c

(Buchon et al., 2009)

dMPK2B

(Martin-Blanco and Martinez Arias, 1997)

dp38c

(Tian et al., 2014)

p38

(Guo et al., 2026, Dahleh et al., 2023, Fox et al., 2020, Gerlach and Herranz, 2020, Gutiérrez-Martínez et al., 2020, Qin et al., 2020, Vizcaya-Molina et al., 2020, Hariharan and Serras, 2017, Jevtov et al., 2015, Buchon et al., 2013, Lee and Brey, 2013)

p38^MAPK

(Zhang and Edgar, 2022)

p38MAPK

(Batista et al., 2016)

Name Synonyms

Mpk2B

p38c

p38c MAP kinase

Secondary FlyBase IDs

FBgn0046322
FBgn0053338
FBgn0020401

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

2768679

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAS65203

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P83100

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P83100

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P83100

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0267339

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

2768679/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0267339

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0267339

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG33338

MARRVEL_MODEL - MARRVEL (model organism gene)

2768679

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0267339

DroID - A comprehensive database of gene and protein interactions.

FBgn0267339

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

p38c_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0046322

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0267339

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0267339

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013594

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

2768679

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (71)

The following external sites may use different assemblies or annotations than FlyBase.

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