FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term MAP kinase activity ID (Ontology) GO:0004707 (Gene Ontology)
Definition Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.[ ISBN:0198547684 ]
Also Known As "ERK1" ; "mitogen activated kinase activity"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       7
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 MAP kinase activity (all annotations which use CV term, excluding "NOT" statements)       1      7
     enables | MAP kinase activity       --       7
Spanning Tree (Parents/Children)
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  protein kinase activity
   |__protein serine/threonine kinase activity
       |__MAP kinase activity  8 rec.
           |__JUN kinase activity 1 rec.
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Is a protein serine/threonine kinase activity
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Synonyms
  • "ATP:protein phosphotransferase (MAPKK-activated) activity" RELATED[ EC:2 ]
    "ERK" RELATED[ EC:2 ]
    "ERK1" EXACT
    "ERK2" RELATED
    "extracellular signal-regulated kinase activity" NARROW[ EC:2 ]
    "MAP kinase 1 activity" NARROW
    "MAP kinase 2 activity" NARROW
    "MAPK" RELATED[ EC:2 PubMed:20811974 ]
    "MBP kinase I activity" NARROW[ EC:2 ]
    "MBP kinase II activity" NARROW[ EC:2 ]
    "mitogen activated kinase activity" EXACT
    "mitogen-activated protein kinase activity" RELATED[ EC:2 ]
    "myelin basic protein kinase activity" NARROW[ EC:2 ]
    "SAP kinase activity" NARROW
    "SAPK" NARROW
    "stress-activated kinase activity" NARROW
    "stress-activated protein kinase activity" NARROW
Secondary IDs
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EC:2.7.11.24
KEGG_REACTION:R00162
MetaCyc:2.7.11.24-RXN
Reactome:R-HSA-111898 "Phosphorylation of cPLA2 by ERK-2"
Reactome:R-HSA-198733 "ERK5 is activated"
Reactome:R-HSA-445079 "Phosphorylation of L1 by ERK"
Reactome:R-HSA-5654560 "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2"
Reactome:R-HSA-5654562 "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2"
Reactome:R-HSA-5654565 "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2"
Reactome:R-HSA-5654566 "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2"
Reactome:R-HSA-73722 "Phosphorylation of UBF-1:rDNA Promoter"
Reactome:R-HSA-9626832 "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345"
Reactome:R-HSA-9825759 "MAPK-dependent phosphorylation of KARS"