FlyBase Allele Report: Dmel\p38c[7B1]

General Information

Symbol

Dmel\p38c^7B1

Species

D. melanogaster

Name

FlyBase ID

FBal0277337

Feature type

allele

Associated gene

Dmel\p38c

Associated Insertion(s)

P{?SUPor-P}p38c^7B1

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Davis et al., 2008)

Progenitor genotype

P{SUPor-P}p38c^KG05834

(Davis et al., 2008)

Associated Insertion(s)

P{?SUPor-P}p38c^7B1

Cytology

Description

Imprecise excision of the progenitor insertion. A 20bp insertion remains, resulting in a frameshift that produces a 232 amino acid protein.

(Davis et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Chakrabarti et al., 2014)

abnormal oxidative stress response

(Chakrabarti et al., 2014)

female sterile

(Davis et al., 2008)

male fertile

(Davis et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

p38c^7B1 mutant flies are more susceptible to Ecc15 infection than wild-type flies.

p38c^7B1 mutant flies are more susceptible to 1% H[[2]]O[[2]] than wild-type flies.

p38c^7B1 mutant flies are more resistant to infection with P.entomophila than wild-type flies. The midguts of infected flies have an increased rate of epithelium renewal compared to controls. No increase in proliferation is seen in uninfected p38c^7B1 mutant flies. Reactive oxygen species levels are lower in the intestines of p38c^7B1 mutants.

p38c^7B1 mutant flies accumulate lipids in the R2b and R5 regions of the midgut. Enlarged lipid droplets are seen in the gut of p38c^7B1 mutants but not in wild type.

(Chakrabarti et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Atf3^Scer\UAS.cSa under the control of Scer\GAL4^{Myo31DF-NP0001} suppresses the decrease in lipid levels seen in the intestines of p38c^7B1 mutant flies.

(Chakrabarti et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

p38c^7B1 is rescued by p38c^+tCa

(Chakrabarti et al., 2014)

Comments

Expression of p38c^+tCa rescues the susceptibility to Ecc15 and P.entomophila infection seen in p38c^7B1 mutant flies. The increased susceptibility to H[[2]]O[[2]] is also rescued. Expression of p38c^+tCa restores the increase in lipid droplet size seen in p38c^7B1 mutants.

(Chakrabarti et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

p38c^7B1

(Kenmoku et al., 2017, Chakrabarti et al., 2014, Davis et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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