FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

p38MAPK cascade

ID (Ontology)

GO:0038066 (Gene Ontology)

Definition

A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.[ PubMed:20811974 PubMed:23125017 PubMed:32794416 ]

Also Known As

"p38 cascade" ; "p38 MAPK cascade"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
p38MAPK cascade (all annotations which use CV term, excluding "NOT" statements)
involved_in \| p38MAPK cascade

Spanning Tree (Parents/Children)

  intracellular signaling cassette
   |__MAPK cascade
       |__p38MAPK cascade  9 rec.
           |__regulation of p38MAPK cascade 3 rec.
               |__negative regulation of p38MAPK cascade
               |__positive regulation of p38MAPK cascade 2 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	MAPK cascade
Part of
Synonyms & Secondary IDs
Synonyms
	"MAPK14 cascade" RELATED "osmosensory signaling MAPK cascade" NARROW "p38 cascade" EXACT[ PubMed:20811974 ] "p38 MAPK cascade" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-450302 "activated TAK1 mediates p38 MAPK activation"