E1021K | Atpalpha-PA; E982K | Atpalpha-PB; E982K | Atpalpha-PC; E982K | Atpalpha-PE; E982K | Atpalpha-PF; E982K | Atpalpha-PG; E982K | Atpalpha-PH; E982K | Atpalpha-PI; E982K | Atpalpha-PJ; E982K | Atpalpha-PK
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
There is no additional reduction in lifespan in eag1, Sh14; AtpαDTS1 triple mutants compared to eag1, Sh14 mutants. The following heterozygous mutants do not enhance the shortened lifespan of AtpαDTS1/+ mutants: eag1, Sh14, and sei1. The short lived phenotype of AtpαDTS1 heterozygotes is enhanced in parats1/+, paraST109/+ and parats115/+ flies. In contrast, heterozygosity for either paralk5 or Df(1)D34 does not shorten the AtpαDTS1 life span. In addition to a shorter lifespan, parats1/+; AtpαDTS1/+ double mutants show an increase in the severity of spongiform neuropathology of the brain at 16 days compared to brains from parats1/+ or AtpαDTS1/+ single mutants. These double mutants show no significant change in temperature sensitivity compared to the single mutants. Like AtpαDTS1 single mutants, parats1; AtpαDTS1 mutants need several minutes to recover from a 3 minute 38oC heat shock. There is no significant change in the lifespan of AtpαDTS1 mutants when they express ShEKO.Scer\UAS.T:Avic\GFP-GL under the control of either Scer\GAL4elav.PLu or Scer\GAL4hs.2sev.