FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\paraST109
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General Information
Symbol
Dmel\paraST109
Species
D. melanogaster
Name
FlyBase ID
FBal0013486
Feature type
allele
Associated gene
Dmel\para
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        paraST109/Df(1)D34 flies do not show a significantly shortened lifespan. However, the brains of these flies show neurodegeneration.

        (Fergestad et al., 2006)

        Viability of double mutant males with mlenap-ts1 is significantly reduced, even at permissive temperatures, though it is possible to maintain a double mutant stock. Double mutant males at 25oC die at or near eclosion.

        (Ganetzky, 1984)

        Reversible heat induced paralysis.

        (Siddiqi and Benzer, 1976)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        paraST109/para[+] is an enhancer of short lived | dominant phenotype of AtpαDTS1

        (Fergestad et al., 2006)
        Other
        Statement
        Reference

        AtpαDTS2, paraST109 has short lived phenotype

        (Fergestad et al., 2006)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The short lived phenotype of AtpαDTS1 heterozygotes is enhanced in paraST109/+ flies. paraST109; AtpαDTS2 double mutants also have a short lifespan of <1 week.

        (Fergestad et al., 2006)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Results from response to cervical stimulation, intracellular recordings of flight muscles and direct excitability of muscle demonstrate the threshold for excitability of a cervical pathway rises at temperatures a few degrees higher than the paralysis temperature while nerve conduction velocity and muscle excitability are still normal.

        (Siddiqi and Benzer, 1976)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        paraST109
        parast109
        (Fergestad et al., 2006)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)