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Citation
Ganetzky, B. (1984). Genetic studies of membrane excitability in Drosophila: Lethal interaction between two temperature-sensitive paralytic mutations.  Genetics 108: 897--911.
FlyBase ID
FBrf0040979
Publication Type
Research paper
Abstract

Two mutants of Drosophila melanogaster, parats1 (1-53.9) and napts (2-56.2) both display similar temperature-sensitive paralysis associated with blockage in the conduction of nerve action potentials, suggesting that the two gene products have a similar function. This idea is supported by the observation that the double mutant is unconditionally lethal. Genetic analysis of this synergistic interaction has revealed the following: it specifically involves the para and nap loci; all para alleles interact with napts, but the strength of the interaction varies in an allele-dependent fashion; lethality of the double mutant occurs during the first larval instar with parats1 but differs with other para alleles; hypodosage of para+ causes lethality in a napts background. These results together with previous electrophysiological, behavioral and pharmacological studies of these mutants suggest that both para and nap affect sodium channels and possibly encode different subunits.

PubMed ID
PubMed Central ID
PMC1224272 (PMC) (EuropePMC)
DOI
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference